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Displaying results 8771 - 8780 of 10000 in total
  1. Drug

    T611

    go.drugbank.com/drugs/DB06391
    Experimental

    T611 is an investigational oral anti-cytomegalovirus (CMV) drug candidate.

    Synonyms: 2-(3S-3-METHYLMORPHOLINO)-4-(IMIDAZOL-1-YL)-6-METHYL-5-NITROPYRIMIDINE BENZENESULFONATE, MORPHOLINE, 4-(4-(1H-IMIDAZOL-1-YL)-6-METHYL-5-NITRO-2-PYRIMIDINYL)-3-METHYL-, (3S)-, BENZENESULFONATE (1:1)
  2. Drug

    Atacicept

    go.drugbank.com/drugs/DB06399
    ApprovedInvestigational

    Atacicept is a recombinant fusion glycoprotein that joins the ligand-binding portion of the human TACI receptor to a modified IgG1 Fc domain, allowing it to bind and neutralize two cytokines: B cell activating … factor (BAFF) and A Proliferation Inducing Ligand (APRIL).

    Categories: Decreased B Lymphocyte Activation, B Lymphocyte Stimulator-specific Inhibitor
  3. Drug

    Ambrisentan

    go.drugbank.com/drugs/DB06403
    ApprovedInvestigational

    Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. … It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening.

    Synonyms: (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acidCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  4. Drug

    Doxercalciferol

    go.drugbank.com/drugs/DB06410
    ApprovedInvestigational

    or Stage 4 chronic kidney disease. … Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin

    Synonyms: 1-Hydroxyvitamin D2, 1-HydroxyergocalciferolCategories: Vitamin D and Analogues
  5. Drug

    Oxymetholone

    go.drugbank.com/drugs/DB06412
    ApprovedIllicit

    The uncontrolled misuse of oxymetholone can lead to a large variety of detrimental effects, the most often reported of which are cardiovascular events. … In 2009, no producers of oxymetholone were identified worldwide (SRI 2009), but it was available from 14 suppliers, including 8 U.S. suppliers (ChemSources 2009).

    Synonyms: 17β-Hydroxy-2-hydroxymethylidene-17α-methyl-3-androstanoneCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 CYP3A Inhibitors
  6. Drug

    Cethromycin

    go.drugbank.com/drugs/DB06419
    Investigational

    Cethromycin is a 3-keto (ketolide) derivative of erythromycin A with an 11,12-carbamate group and an O-6-linked aromatic ring system. … [A203369] Cethromycin represents a joint development effort by Abbott Laboratories, Taisho Pharmaceuticals, and Advanced Life Sciences, intended to be marketed under the trade name Restanza for the treatment

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  7. Drug

    Annamycin

    go.drugbank.com/drugs/DB06420
    Investigational

    Synonyms: 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicinCategories: P-glycoprotein inhibitors
  8. Drug

    TAK-751S

    go.drugbank.com/drugs/DB06432
    Investigational

    TAK-751S is a synthetic analog of Shiga toxin (Stx) receptor, Gb3, produced by enterohemorrhagic _Escherichia coli_.[A260296]

  9. Drug

    Lonafarnib

    go.drugbank.com/drugs/DB06448
    ApprovedInvestigational

    [A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … aberrant farnesylated form of lamin A called progerin in the inner nuclear membrane.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  10. Drug

    Aprinocarsen

    go.drugbank.com/drugs/DB06451
    Investigational

    Aprinocarsen is a specific antisense oligonucleotide inhibitor of protein kinase C-alpha.

    Categories: Protein Kinase C, antagonists & inhibitors