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Inclisiran
go.drugbank.com/drugs/DB14901ApprovedInvestigational[A225953,A225958] Lowering circulating plasma LDL-C levels offers an additional benefit of reducing the risk of cardiovascular disease (CVD) and improving cardiovascular outcomes, as hypercholesterolemia … Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density
Categories: Compounds used in a research, industrial, or household setting, Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: LYPTİMZİA 284 MG/1,5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETTimbetasin
go.drugbank.com/drugs/DB19119InvestigationalTimbetasin is under investigation in clinical trial NCT05555589 (Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2).
Synonyms: 3,11,25,31,38-pentakis(de-n6-acetyl)-1,22,30,33-tetrakis(de-o3-phosphono)thymosin .beta.4(human), Thymosin .beta.(4), 3,11,25,31,38-pentakis(de-n6-acetyl)-1,22,30,33-tetrakis(de-o3-phosphono)-Nandrolone decanoate
go.drugbank.com/drugs/DB08804ApprovedIllicitInvestigationalNandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile … [A233849] Nandrolone decanoate was granted FDA approval on 5 October 1962.[L32564]
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesProducts: PARABOLIN RETARD 5 MG AMPUL, 2 ADET, DECA - DURABOLIN® 50 MGViltolarsen
go.drugbank.com/drugs/DB15005ApprovedInvestigationalDuchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function … [A218161, A218166, A218171, A218176, A218181, A218191, L15526] These shortened forms of dystrophin can restore partial muscle function and slow the progression of DMD.
Lorlatinib
go.drugbank.com/drugs/DB12130ApprovedInvestigationalIt was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to … include lorlatinib as a first-line treatment option in advanced ALK-positive NSCLC.
Categories: MATE 1 Inhibitors, P-glycoprotein inducersProducts: LORBRENA® 25 MG, LORBRENA® 100 MGBrompheniramine
go.drugbank.com/drugs/DB00835ApprovedHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Synonyms: 3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine, 3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamineMixtures: Brom Mal Phenyl HCl Dex HBr, J-tan D PdBenzatropine
go.drugbank.com/drugs/DB00245ApprovedInvestigationalThe generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased … It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970.
Synonyms: benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether, 3α-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octaneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesNonivamide
go.drugbank.com/drugs/DB11324ApprovedNonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an amide of pelargonic acid and _vanillylamine_. … It is an alkaloid from the Capsicum species.
Mixtures: Nonivamid + Nicoboxil Zentiva 4 mg/g + 25 mg/g SalbeSynonyms: N-Vanillylnonamide, N-Nonanoyl vanillylamideExemestane
go.drugbank.com/drugs/DB00990ApprovedInvestigationalExemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal
Synonyms: 6-methyleneandrosta-1,4-diene-3,17-dioneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAlipogene tiparvovec
go.drugbank.com/drugs/DB13521ApprovedAlipogene tiparvovec is an adeno-associated viral vector of serotype 1-based gene therapy that delivers the Ser(447)X variant of the human lipoprotein lipase (LPL) gene.