Identification
- Summary
Nandrolone decanoate is an anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass.
- Generic Name
- Nandrolone decanoate
- DrugBank Accession Number
- DB08804
- Background
Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.8,11,12,13 The process for creating esters of nandrolone was patented in Spain in 195915 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters.11
Nandrolone decanoate was granted FDA approval on 5 October 1962.12
- Type
- Small Molecule
- Groups
- Approved, Illicit
- Structure
Structure for Nandrolone decanoate (DB08804)
- Weight
- Average: 428.6472
Monoisotopic: 428.329045274 - Chemical Formula
- C28H44O3
- Synonyms
- 19-nortestosterone decanoate
- Nandrolone 17β-decanoate
- Nandrolone decanoate
Pharmacology
- Indication
Nandrolone decanoate is indicated in the management of anemia of renal insufficiency.12 In Canada, it is also indicated as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.13
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Nandrolone decanoate is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.8,12,13 It has a long duration of action as it is given every 3-4 weeks, and a wide therapeutic window as acute overdoses are rare.8,13 Patients should be counselled regarding the risks of giving this drug to patients with cardiac, renal, or hepatic diseases.13
- Mechanism of action
Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B.3,5 Nandrolone is brought into cells by receptor mediated endocytosis, where it interacts with the androgen receptor.9,10 After binding to the androgen receptor, a conformational change occurs, the androgen receptor enters the nucleus, dimerizes, and can then bind to segments of DNA to regulate transcription.10 Androgens can also regulate transcription through activation of ERK, Akt, and MAPK; or binding to and competitively inhibiting transcription factors.10
Target Actions Organism AAndrogen receptor agonistHumans UProto-oncogene c-Fos inducerHumans U5-hydroxytryptamine 2 receptor modulatorHumans U5-hydroxytryptamine receptor 1B modulatorHumans UInsulin-like growth factor 1 receptor inducerHumans UDopamine receptor modulatorHumans - Absorption
A 50 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 2.14 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 400 h*ng/mL.1 A 100 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 4.26 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 862 h*ng/mL.1 A 150 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 5.16 ng/mL, with a mean Tmax of 72 hours, and a mean AUC of 1261 h*ng/mL.1
- Volume of distribution
Not Available
- Protein binding
Data regarding the percent protein binding of nandrolone decanoate is not readily available. After nandrolone decanoate is hydrolyzed to nandrolone, it is bound to sex hormone binding globulin.6
- Metabolism
Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B.3,5 Nandrolone is further metabolized to the urinary metabolites 19-norandrosterone, 19-noretiocholanolone, and 19-norepiandrosterone.2,13 19-norandrosterone is 3-O-glucuronidated by UGT2B7, UGT 1A4, UGT2B4, UGT1A3, and UGT1A1.4 19-noretiocholanolone is 3-O-glucuronidated by UGT2B7, UGT2B4, UGT1A4, UGT1A10, UGT1A3, and UGT1A1.4
Hover over products below to view reaction partners
- Route of elimination
Nandrolone decanoate is eliminated as urinary metabolites, however data regarding elimination in the feces are not readily available.7 Data in cattle shows that nandrolone is 30% eliminated in the feces.7
- Half-life
Nandrolone decanoate has an absorption half life of 6 days and an elimination half life of 4.3 hours.13 Alternate studies have shown that nandrolone decanoate has a terminal half life of 7.1, 11.7, and 11.8 hours for doses of 50, 100, and 150 mg respectively.1
- Clearance
50 mg, 100 mg, and 150 mg doses of nadrolone decanoate had mean apparent clearances of 80.0 L/h, 74.3 L/h, and 76.2 L/h respectively.1
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Data regarding acute overdose of nandrolone decanoate are not readily available.13 However, patients experiencing a chronic overdose of anabolic steroids may experience adverse effects including suppression of testosterone and spermatogenesis, shrinking of testicles, decreased libido, and erectile dysfunction in men; and suppressed estrogen, progesterone, and ovulation, amenorrhea, and clitoromegaly in women.8 Patients may also experience neuropsychiatric, cardiovascular, and hepatic adverse effects.8 Alkylated anabolic steroids such as nandrolone decanoate are more likely to cause hepatic adverse effects.8 Treat patients with symptomatic and supportive measures.
The intraperitoneal LD50 in mice is >566 mg/kg.14
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcarbose Nandrolone decanoate may increase the hypoglycemic activities of Acarbose. Acenocoumarol Nandrolone decanoate may increase the anticoagulant activities of Acenocoumarol. Acetohexamide Nandrolone decanoate may increase the hypoglycemic activities of Acetohexamide. Albiglutide Nandrolone decanoate may increase the hypoglycemic activities of Albiglutide. Allantoin The therapeutic efficacy of Allantoin can be increased when used in combination with Nandrolone decanoate. Almotriptan The metabolism of Almotriptan can be decreased when combined with Nandrolone decanoate. Alogliptin Nandrolone decanoate may increase the hypoglycemic activities of Alogliptin. Beclomethasone dipropionate The risk or severity of edema formation can be increased when Nandrolone decanoate is combined with Beclomethasone dipropionate. Betamethasone The risk or severity of edema formation can be increased when Nandrolone decanoate is combined with Betamethasone. Betamethasone phosphate The risk or severity of edema formation can be increased when Nandrolone decanoate is combined with Betamethasone phosphate. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Nandrolone prodrug 6PG9VR430D 434-22-0 NPAGDVCDWIYMMC-IZPLOLCNSA-N - International/Other Brands
- Deca-Durabol / Deca-Durabolin / Retabolil
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Nandrolone Decanoate Injection 200 mg/1mL Intramuscular Watson Pharmaceuticals 2007-02-08 Not applicable US 
Nandrolone Decanoate Injection 100 mg/1mL Intramuscular Watson Pharmaceuticals 2007-02-08 Not applicable US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Nandrolone Decanoate Injection, solution 200 mg/1mL Intramuscular AMERICAN REGENT, INC. 2010-09-01 2010-10-01 US
Categories
- Drug Categories
- Anabolic Agents
- Androgens
- Bone Density Conservation Agents
- Estranes
- Estrenes
- Fused-Ring Compounds
- Gonadal Hormones
- Gonadal Steroid Hormones
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates
- Nandrolone and esters
- Steroids
- Testosterone Congeners
- Thyroxine-binding globulin inhibitors
- UGT1A1 Substrates
- UGT1A3 substrates
- UGT1A4 substrates
- UGT2B7 substrates
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Steroid esters
- Direct Parent
- Steroid esters
- Alternative Parents
- Estrogens and derivatives / 3-oxo delta-4-steroids / Delta-4-steroids / Cyclohexenones / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives
- Substituents
- 3-oxo-delta-4-steroid / 3-oxosteroid / Aliphatic homopolycyclic compound / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Cyclic ketone / Cyclohexenone / Delta-4-steroid / Estrane-skeleton
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- steroid ester (CHEBI:7467)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- H45187T098
- CAS number
- 360-70-3
- InChI Key
- JKWKMORAXJQQSR-MOPIKTETSA-N
- InChI
- InChI=1S/C28H44O3/c1-3-4-5-6-7-8-9-10-27(30)31-26-16-15-25-24-13-11-20-19-21(29)12-14-22(20)23(24)17-18-28(25,26)2/h19,22-26H,3-18H2,1-2H3/t22-,23+,24+,25-,26-,28-/m0/s1
- IUPAC Name
- (1S,3aS,3bR,9aR,9bS,11aS)-11a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl decanoate
- SMILES
- [H][C@@]12CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
References
- General References
- Bagchus WM, Smeets JMW, Verheul HAM, De Jager-Van Der Veen SM, Port A, Guerts TBP: Pharmacokinetic Evaluation of Three Different Intramuscular Doses of Nandrolone Decanoate: Analysis of Serum and Urine Samples in Healthy Men The Journal of Clinical Endocrinology & Metabolism. 2005 May 1;90(5):2624-2630. [Article]
- Baume N, Avois L, Schweizer C, Cardis C, Dvorak J, Cauderay M, Mangin P, Saugy M: [13C]Nandrolone excretion in trained athletes: interindividual variability in metabolism. Clin Chem. 2004 Feb;50(2):355-64. doi: 10.1373/clinchem.2003.022848. Epub 2003 Nov 21. [Article]
- Wijnand HP, Bosch AM, Donker CW: Pharmacokinetic parameters of nandrolone (19-nortestosterone) after intramuscular administration of nandrolone decanoate (Deca-Durabolin) to healthy volunteers. Acta Endocrinol Suppl (Copenh). 1985;271:19-30. doi: 10.1530/acta.0.109s00019. [Article]
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
- Strahm E, Rane A, Ekstrom L: PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2. Front Pharmacol. 2014 May 30;5:132. doi: 10.3389/fphar.2014.00132. eCollection 2014. [Article]
- Victor A, Weiner E, Johansson ED: Sex hormone binding globulin: the carrier protein for d-norgestrel. J Clin Endocrinol Metab. 1976 Jul;43(1):244-7. doi: 10.1210/jcem-43-1-244. [Article]
- Calvarese S, Rubini P, Urbani G, Ferri N, Ramazza V, Zucchi M: Experimental administration of 19-nortestosterone and dexamethasone in cattle: elimination of the two drugs in different biological matrices. Analyst. 1994 Dec;119(12):2611-5. doi: 10.1039/an9941902611. [Article]
- Anawalt BD: Diagnosis and Management of Anabolic Androgenic Steroid Use. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2490-2500. doi: 10.1210/jc.2018-01882. [Article]
- Chen HC, Farese RV: Steroid hormones: Interactions with membrane-bound receptors. Curr Biol. 1999 Jul 1;9(13):R478-81. doi: 10.1016/s0960-9822(99)80300-5. [Article]
- Pan MM, Kovac JR: Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness. Transl Androl Urol. 2016 Apr;5(2):213-9. doi: 10.21037/tau.2016.03.03. [Article]
- de VISSER, OVERBEEK GA: Pharmacological properties of nandrolone decanoate. Acta Endocrinol (Copenh). 1960 Nov;35:405-12. doi: 10.1530/acta.0.xxxv0405. [Article]
- FDA Approved Drug Products: Deca-Durabolin (Nandrolone Decanoate) Injection (Discontinued) [Link]
- DPD Approved Drugs: Durabolin [Link]
- Jurox: Reepair Injection MSDS [Link]
- Spain Patent: ES246402A1 [Link]
- External Links
- Human Metabolome Database
- HMDB0015694
- KEGG Drug
- D00955
- KEGG Compound
- C08154
- PubChem Compound
- 9677
- PubChem Substance
- 99445274
- ChemSpider
- 9296
- 31494
- ChEBI
- 7467
- ChEMBL
- CHEMBL1200946
- ZINC
- ZINC000008214619
- Therapeutic Targets Database
- DAP000903
- PharmGKB
- PA165958423
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Nandrolone_decanoate
- MSDS
- Download (49.5 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Supportive Care Hip Fracture 1 1 Completed Treatment HIV Wasting Syndrome / Human Immunodeficiency Virus (HIV) Infections 1 1, 2 Completed Treatment Aplastic Anemia / Bone Marrow Failure Syndromes / Idiopathic Pulmonary Fibrosis (IPF) / Telomere Shortening 1 Not Available Completed Supportive Care Cancer Cachexia 1 Not Available Completed Treatment End Stage Renal Disease (ESRD) / Muscle Weakness 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intramuscular 50 mg Solution Intramuscular 100 mg / mL Liquid Intramuscular 50 mg / mL Injection, solution Parenteral Injection Intramuscular 25 mg/ml Injection, solution 250 mg/1ml Injection Intramuscular 100 mg/1mL Injection Intramuscular 200 mg/1mL Injection, solution Intramuscular 200 mg/1mL Injection Intramuscular; Subcutaneous 25 mg Injection Intramuscular; Subcutaneous 5 mg - Prices
Unit description Cost Unit Deca-Durabolin 100 mg/ml 97.16USD ml Nandrolone decanoate powder 79.88USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 32-35 Health Canada water solubility 3.09 mg/mL at 25 °C YALKOWSKY,SH & HE,Y (2003) - Predicted Properties
Property Value Source Water Solubility 0.000157 mg/mL ALOGPS logP 5.96 ALOGPS logP 7.32 Chemaxon logS -6.4 ALOGPS pKa (Strongest Acidic) 18.25 Chemaxon pKa (Strongest Basic) -4.7 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 43.37 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 125.94 m3·mol-1 Chemaxon Polarizability 53.64 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 1.0 Blood Brain Barrier + 0.97 Caco-2 permeable + 0.6718 P-glycoprotein substrate Substrate 0.6327 P-glycoprotein inhibitor I Inhibitor 0.8364 P-glycoprotein inhibitor II Inhibitor 0.5069 Renal organic cation transporter Non-inhibitor 0.7532 CYP450 2C9 substrate Non-substrate 0.8741 CYP450 2D6 substrate Non-substrate 0.9285 CYP450 3A4 substrate Substrate 0.72 CYP450 1A2 substrate Non-inhibitor 0.94 CYP450 2C9 inhibitor Non-inhibitor 0.8841 CYP450 2D6 inhibitor Non-inhibitor 0.9111 CYP450 2C19 inhibitor Non-inhibitor 0.5353 CYP450 3A4 inhibitor Non-inhibitor 0.7896 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.5493 Ames test Non AMES toxic 0.9431 Carcinogenicity Non-carcinogens 0.9215 Biodegradation Not ready biodegradable 0.9625 Rat acute toxicity 1.8804 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8573 hERG inhibition (predictor II) Non-inhibitor 0.7636
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Zinc ion binding
- Specific Function
- Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
- Gene Name
- AR
- Uniprot ID
- P10275
- Uniprot Name
- Androgen receptor
- Molecular Weight
- 98987.9 Da
References
- Birgner C, Kindlundh-Hogberg AM, Alsio J, Lindblom J, Schioth HB, Bergstrom L: The anabolic androgenic steroid nandrolone decanoate affects mRNA expression of dopaminergic but not serotonergic receptors. Brain Res. 2008 Nov 13;1240:221-8. doi: 10.1016/j.brainres.2008.09.003. Epub 2008 Sep 13. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Transcriptional activator activity, rna polymerase ii core promoter proximal region sequence-specific binding
- Specific Function
- Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with s...
- Gene Name
- FOS
- Uniprot ID
- P01100
- Uniprot Name
- Proto-oncogene c-Fos
- Molecular Weight
- 40694.855 Da
References
- Johansson-Steensland P, Nyberg F, Chahl L: The anabolic androgenic steroid, nandrolone decanoate, increases the density of Fos-like immunoreactive neurons in limbic regions of guinea-pig brain. Eur J Neurosci. 2002 Feb;15(3):539-44. doi: 10.1046/j.0953-816x.2001.01877.x. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Modulator
- General Function
- Virus receptor activity
- Specific Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodop...
Components:
| Name | UniProt ID |
|---|---|
| 5-hydroxytryptamine receptor 2A | P28223 |
| 5-hydroxytryptamine receptor 2B | P41595 |
| 5-hydroxytryptamine receptor 2C | P28335 |
References
- Kindlundh AM, Lindblom J, Bergstrom L, Nyberg F: The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Neuroscience. 2003;119(1):113-20. doi: 10.1016/s0306-4522(03)00120-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Modulator
- General Function
- Serotonin receptor activity
- Specific Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive subst...
- Gene Name
- HTR1B
- Uniprot ID
- P28222
- Uniprot Name
- 5-hydroxytryptamine receptor 1B
- Molecular Weight
- 43567.535 Da
References
- Kindlundh AM, Lindblom J, Bergstrom L, Nyberg F: The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Neuroscience. 2003;119(1):113-20. doi: 10.1016/s0306-4522(03)00120-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Protein tyrosine kinase activity
- Specific Function
- Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involv...
- Gene Name
- IGF1R
- Uniprot ID
- P08069
- Uniprot Name
- Insulin-like growth factor 1 receptor
- Molecular Weight
- 154791.73 Da
References
- Gayan-Ramirez G, Rollier H, Vanderhoydonc F, Verhoeven G, Gosselink R, Decramer M: Nandrolone decanoate does not enhance training effects but increases IGF-I mRNA in rat diaphragm. J Appl Physiol (1985). 2000 Jan;88(1):26-34. doi: 10.1152/jappl.2000.88.1.26. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Modulator
- General Function
- G-protein coupled amine receptor activity
- Specific Function
- Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Components:
| Name | UniProt ID |
|---|---|
| D(1A) dopamine receptor | P21728 |
| D(1B) dopamine receptor | P21918 |
| D(2) dopamine receptor | P14416 |
| D(3) dopamine receptor | P35462 |
| D(4) dopamine receptor | P21917 |
References
- Kindlundh AM, Lindblom J, Bergstrom L, Wikberg JE, Nyberg F: The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain. Eur J Neurosci. 2001 Jan;13(2):291-6. doi: 10.1046/j.0953-816x.2000.01402.x. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Oxygen binding
- Specific Function
- Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
- Gene Name
- CYP19A1
- Uniprot ID
- P11511
- Uniprot Name
- Aromatase
- Molecular Weight
- 57882.48 Da
References
- Takahashi K, Hallberg M, Magnusson K, Nyberg F, Watanabe Y, Langstrom B, Bergstrom M: Increase in [11C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids. Neuroreport. 2007 Jan 22;18(2):171-4. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Primary amine oxidase activity
- Specific Function
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral...
- Gene Name
- MAOB
- Uniprot ID
- P27338
- Uniprot Name
- Amine oxidase [flavin-containing] B
- Molecular Weight
- 58762.475 Da
References
- Birgner C, Kindlundh-Hogberg AM, Oreland L, Alsio J, Lindblom J, Schioth HB, Bergstrom L: Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Brain Res. 2008 Jul 11;1219:103-10. doi: 10.1016/j.brainres.2008.05.014. Epub 2008 May 17. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Serotonin binding
- Specific Function
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral...
- Gene Name
- MAOA
- Uniprot ID
- P21397
- Uniprot Name
- Amine oxidase [flavin-containing] A
- Molecular Weight
- 59681.27 Da
References
- Birgner C, Kindlundh-Hogberg AM, Oreland L, Alsio J, Lindblom J, Schioth HB, Bergstrom L: Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Brain Res. 2008 Jul 11;1219:103-10. doi: 10.1016/j.brainres.2008.05.014. Epub 2008 May 17. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Glucuronosyltransferase activity
- Specific Function
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su...
- Gene Name
- UGT2B7
- Uniprot ID
- P16662
- Uniprot Name
- UDP-glucuronosyltransferase 2B7
- Molecular Weight
- 60694.12 Da
References
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Protein homodimerization activity
- Specific Function
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the...
- Gene Name
- UGT1A4
- Uniprot ID
- P22310
- Uniprot Name
- UDP-glucuronosyltransferase 1-4
- Molecular Weight
- 60024.535 Da
References
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Glucuronosyltransferase activity
- Specific Function
- UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as...
- Gene Name
- UGT2B4
- Uniprot ID
- P06133
- Uniprot Name
- UDP-glucuronosyltransferase 2B4
- Molecular Weight
- 60512.035 Da
References
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Retinoic acid binding
- Specific Function
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative reg...
- Gene Name
- UGT1A3
- Uniprot ID
- P35503
- Uniprot Name
- UDP-glucuronosyltransferase 1-3
- Molecular Weight
- 60337.835 Da
References
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid binding
- Specific Function
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the...
- Gene Name
- UGT1A1
- Uniprot ID
- P22309
- Uniprot Name
- UDP-glucuronosyltransferase 1-1
- Molecular Weight
- 59590.91 Da
References
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Protein kinase c binding
- Specific Function
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative reg...
- Gene Name
- UGT1A10
- Uniprot ID
- Q9HAW8
- Uniprot Name
- UDP-glucuronosyltransferase 1-10
- Molecular Weight
- 59809.075 Da
References
- Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [Article]
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Binder
- General Function
- Androgen binding
- Specific Function
- Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone...
- Gene Name
- SHBG
- Uniprot ID
- P04278
- Uniprot Name
- Sex hormone-binding globulin
- Molecular Weight
- 43778.755 Da
References
- Victor A, Weiner E, Johansson ED: Sex hormone binding globulin: the carrier protein for d-norgestrel. J Clin Endocrinol Metab. 1976 Jul;43(1):244-7. doi: 10.1210/jcem-43-1-244. [Article]
Drug created at June 13, 2005 13:24 / Updated at May 07, 2021 21:06