Nandrolone decanoate is an anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass. The process for creating esters of nandrolone was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other...
- Mechanism
- Curator reviewed · 6 references
Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B. Nandrolone is brought into cells by receptor mediated endocytosis, where it interacts with the androgen receptor. After binding to the androgen receptor, a conformational change occurs, the androgen receptor enters the nucleus, dimerizes, and can then bind to segments of DNA to regulate transcription. Androgens can also regulate transcription through activation of ERK, Akt, and MAPK; or binding to and competitively inhibiting transcription factors.
- Primary indication
- Nandrolone decanoate is indicated in the management of anemia of renal insufficiency.Curator reviewed · 3 structured indications
- Formula / weight
- C28H44O3 · 428.6472 g/mol (avg)
- First approval
- Canada, 2009 · United States, 2007
Resolves to
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Which drugs share a target with Nandrolone decanoate, and which of those have an active Phase 3 trial?
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