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Flupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawn[A229083] Flupentixol is an antagonist of both D1 and D2 dopamine receptors. … It is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity.
Categories: Dopamine D2 Receptor AntagonistsEthinylestradiol
go.drugbank.com/drugs/DB00977ApprovedInvestigational[A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]
Mixtures: Aviane 28 Day, Apri 28 DayTalazoparib
go.drugbank.com/drugs/DB11760ApprovedInvestigationalTalazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. … [L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and by the EMA in June 2019.[L47296] It was approved by Health Canada in September 2020.
Categories: P-glycoprotein substrates with a Narrow Therapeutic IndexTrimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approvedprevents the synthesis of bacterial DNA and ultimately continued bacterial survival. … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it
Mixtures: Bactrim DS, Bactrim DSBacitracin
go.drugbank.com/drugs/DB00626ApprovedInvestigationalVet approvedBacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. … [A181952] The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy.
Mixtures: Dr Bells Pomade, Pomada De La Campana Triple Antibiotic Pain ReliefSynonyms: Bacitracin AMidazolam
go.drugbank.com/drugs/DB00683ApprovedIllicitInvestigational[F2977] This drug was initially approved by the US FDA in 1985, and has been approved for various indications since. … [L45098] In late 2018, the intramuscular preparation was approved by the FDA for the treatment of status epilepticus in adults.
Products: N/aInositol
go.drugbank.com/drugs/DB13178ApprovedInvestigationalWithdrawnIt is considered a pseudovitamin as it is a molecule that does not qualify to be an essential vitamin because even though its presence is vital in the body, a deficiency in this molecule does not translate … [L1113] By the FDA, inositol is considered in the list of specific substances affirmed as generally recognized as safe (GRAS).[L2561]
Mixtures: One A Day Tab, Extra Once A DayCategories: Vitamin B ComplexRopinirole
go.drugbank.com/drugs/DB00268ApprovedInvestigationalRopinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. … Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], [A174547].
Products: ROPINIROL 1A PHARMA 1MG, ROPINIROL 1A PHARMA 2MGEntacapone
go.drugbank.com/drugs/DB00494ApprovedInvestigationalWhen administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration … of levodopa and a decarboxylase inhibitor.
Mixtures: LCE 1A PHARMA 100/25/200, LCE 1A PHARMA 100/25/200Mifamurtide
go.drugbank.com/drugs/DB13615ApprovedInvestigationalAs a liposomal formulation, mifamurtide demonstrates an enhanced tumoricidal effect and improved safety profile [A31745]. Mifamurtide is marketed in Europe as Mepact for intravenous infusion. … Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP).