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Displaying results 8871 - 8880 of 10000 in total
  1. Drug

    Foretinib

    go.drugbank.com/drugs/DB12307
    Investigational

    Foretinib is an orally available small molecule compound designed to target multiple RTKs implicated in the development, progression and spread of cancer.

    Categories: Heterocyclic Compounds, 2-Ring
  2. Drug

    Idasanutlin

    go.drugbank.com/drugs/DB12325
    Investigational

    Idasanutlin has been used in trials studying the treatment of Neoplasms, Non-Hodgkin's Lymphoma, Leukemia, Myeloid, Acute, Recurrent Plasma Cell Myeloma, and Neoplasms, Leukemia, Acute Myeloid Leukemia.

    Synonyms: BENZOIC ACID, 4-((((2R,3S,4R,5S)-3-(3-CHLORO-2-FLUOROPHENYL)-4-(4-CHLORO-2-FLUOROPHENYL)-4-CYANO-5-(2,2-DIMETHYLPROPYL)-2-PYRROLIDINYL)CARBONYL)AMINO)-3-METHOXY-Categories: Heterocyclic Compounds, 1-Ring, Proto-Oncogene Proteins c-mdm2, antagonists & inhibitors
  3. Drug

    Salvinorin A

    go.drugbank.com/drugs/DB12327
    Investigational

    Salvinorin A has been investigated for the basic science of Pharmaceutical Preparations.

    Synonyms: Salvinorin A
  4. Drug

    Rucaparib

    go.drugbank.com/drugs/DB12332
    ApprovedInvestigational

    [A249240] The drug was later approved by the European Commission in May 2018.[L42185] It is currently used to treat recurrent ovarian and prostate cancer in adults.[L42155,L42185]. … Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
  5. Drug

    Amcipatricin

    go.drugbank.com/drugs/DB12333
    Investigational

    SPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone … In preclinical models, SPK-843 shows in vitro inhibitory activity comparable to or better than that of Amphotericin B against Candida spp., Cryptococcus neoformans, and Aspergillus spp.

  6. Drug

    Navitoclax

    go.drugbank.com/drugs/DB12340
    Investigational

    Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer.

    Synonyms: (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-Trifluoromethanesulfonylbenzenesulfonamide
  7. Drug

    Nilofabicin

    go.drugbank.com/drugs/DB12347
    Investigational

    CG400549 has been used in trials studying the treatment of Skin Infection.

    Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    5-amino-1,3,4-thiadiazole-2-thiol

    go.drugbank.com/drugs/DB12348
    Investigational

    ATT has been investigated in Pulmonary Tuberculosis.

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Piclozotan

    go.drugbank.com/drugs/DB12361
    Investigational

    Piclozotan has been investigated for the treatment of Parkinson's Disease.

    Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor Agonists
  10. Drug

    Vestronidase alfa

    go.drugbank.com/drugs/DB12366
    ApprovedInvestigational

    Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. … The enzyme is a homotetramer consisted of 4 monomers with 629 amino acids, and holds the same amino acid sequence as human beta-glucuronidase (GUS) [FDA Label].