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Bedaquiline
go.drugbank.com/drugs/DB08903ApprovedInvestigationalBedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. … The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity.
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisRiltozinameran
go.drugbank.com/drugs/DB17095ApprovedInvestigationalIt is administered in combination with [tozinameran] for active immunization against COVID-19 caused by SARS-CoV-2, including infection caused by Omicron BA.1[L45419] … BA.4, BA.5) which, although similar, may behave differently from one another.[L43917] Riltozinameran is an mRNA vaccine encoding the S glycoprotein of SARS-CoV-2 Omicron variant lineage BA.1.
Mixtures: Comirnaty Original/omicron Ba.1Thyrotropin alfa
go.drugbank.com/drugs/DB00024ApprovedInvestigationalVet approvedThyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. … gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH).
Products: Thyrogen 0.9 mg Powder for Solution for InjectionZucapsaicin
go.drugbank.com/drugs/DB09120ApprovedWithdrawnIt is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1, that reduces pain and improves articular functions. … Zucapsaicin has also been evaluated for the management of several conditions manifested by chronic nerve pain.
Categories: Topical Products for Joint and Muscular PainButalbital
go.drugbank.com/drugs/DB00241ApprovedIllicitButalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. … As with other barbiturates, butalbital carries a risk of abuse or misuse potential, intoxication, hangover, tolerance, dependence, and overdosage possibly leading to death.
Mixtures: Vtol LQ, Alagesic LQLoncastuximab tesirine
go.drugbank.com/drugs/DB16222ApprovedInvestigational[A234439] Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival. … Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success.
Synonyms: Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through A protease cleavable valine-alanine linkerGlofitamab
go.drugbank.com/drugs/DB16371ApprovedInvestigationalGlofitamab is a full-length bispecific monoclonal antibody with affinity for both CD20 and CD3 surface antigens found on B- and T-cells, respectively. … It has a 2:1 configuration, with bivalency towards CD20 and monovalency towards CD3, and works by recruiting T-cells directly to the surface of cancerous B-cells.
Heparin
go.drugbank.com/drugs/DB01109ApprovedInvestigationalUnfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. … Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Categories: Heparins or Heparinoids for Topical UseProducts: BRAUN HEPARINISED SALINE 10IU/ML SOLUTION FOR INJECTION, HEPARIN AL GEL 30000Retifanlimab
go.drugbank.com/drugs/DB15766ApprovedInvestigationalOn October 2021, Incyte Biosciences withdrew its application for a marketing authorization of retifanlimab for the treatment of squamous carcinoma of the anal canal. … death-ligand 2 (PD-L2).
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors