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Belinostat
go.drugbank.com/drugs/DB05015ApprovedInvestigationalIt was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma. … Intravenous administration of the agent is available as Beleodaq as monotherapy and the dosing regimen involves a 21-day cycle.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic IndexSynonyms: (2E)-N-HYDROXY-3-(3-(PHENYLSULFAMOYL)PHENYL)PROP-2-ENAMIDE, 2-PROPENAMIDE, N-HYDROXY-3-(3-((PHENYLAMINO)SULFONYL)PHENYL)-Mitoquinone
go.drugbank.com/drugs/DB05063Investigational-- where they accumulate up to a thousand fold. … Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes
Lobeline
go.drugbank.com/drugs/DB05137InvestigationalAn alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. … It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation. [PubChem]
Categories: Heterocyclic Compounds, 1-RingPretomanid
go.drugbank.com/drugs/DB05154ApprovedInvestigationalPersistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. … It was the first TB drug developed by a nonprofit organization, known as TB Alliance, and was granted FDA approval on August 14, 2019.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesVintafolide
go.drugbank.com/drugs/DB05168InvestigationalVintafolide is a folate-targeted chemotherapeutic conjugate (folate vitamin + vinca alkaloid) in clinical stage development as a treatment for folate-receptor positive cancers.
Categories: Heterocyclic Compounds, 2-RingBezisterim
go.drugbank.com/drugs/DB05212InvestigationalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesKojic acid
go.drugbank.com/drugs/DB01759ApprovedMixtures: Ultra-Potent 2% Kojic Acid GlowingCategories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingDihydroxyacetone
go.drugbank.com/drugs/DB01775ExperimentalA ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. … It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent. [PubChem]
Quinolinic Acid
go.drugbank.com/drugs/DB01796ExperimentalA metabolite of tryptophan with a possible role in neurodegenerative disorders.
Categories: Heterocyclic Compounds, 1-RingCordycepin Triphosphate
go.drugbank.com/drugs/DB01860ExperimentalCategories: Heterocyclic Compounds, 2-Ring