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Medical Cannabis
go.drugbank.com/drugs/DB14009Investigational1:1 formulation with CBD from purified plant extract as [DB14011]. … There is further evidence that CBD also activates 5-HT1A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline
Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsNabiximols
go.drugbank.com/drugs/DB14011InvestigationalNabiximols (tradename Sativex®) is a whole plant extract from the Cannabis species _Cannabis sativa L._ that has been purified into the active components CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol … Sativex® is available in a 1:1 formulation of THC:CBD as an oro-mucosal pump spray used for treatment of neuropathic pain from Multiple Sclerosis (MS) and for intractable cancer pain.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSR-9011
go.drugbank.com/drugs/DB14014ExperimentalSR-9011 is a REV-ERB agonist. … SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues
Synonyms: 1-Pyrrolidinecarboxamide, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-n-pentyl-Categories: Heterocyclic Compounds, 1-RingH3B-8800
go.drugbank.com/drugs/DB14017InvestigationalH3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine [L2551].
Synonyms: (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate, (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-Dimethyl-12-Oxo-2-[(2E,4E,6R)-6-(Pyridin-2-Yl)Hepta-2,4-Dien-2-Yl]Oxacyclododec-4-En-6-Yl 4-Methylpiperazine-1-CarboxylateCategories: Heterocyclic Compounds, 1-RingFosnetupitant
go.drugbank.com/drugs/DB14019ApprovedInvestigationalFood and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg … Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting
Categories: Substance P/Neurokinin-1 Receptor Antagonist, Cytochrome P-450 CYP3A InhibitorsNordazepam
go.drugbank.com/drugs/DB14028InvestigationalAn intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
Synonyms: N-desmethyldiazepamCategories: Heterocyclic Compounds, 2-RingTretamine
go.drugbank.com/drugs/DB14031ExperimentalToxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.
Synonyms: 2,4,6-tris(1-aziridinyl)-s-triazine, 2,4,6-tri(1-aziridinyl)-1,3,5-triazineCategories: Heterocyclic Compounds, 1-RingEnglitazone
go.drugbank.com/drugs/DB14035ExperimentalEnglitazone is a hypoglycemic agent.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingHopantenic acid
go.drugbank.com/drugs/DB14044ExperimentalHopantenic acid (Pantogam) is a central nervous system depressant. … Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal syndrome. [A33115]
Synonyms: N-pantoyl-GABA, D-Homopantothenic acidCholesteryl chloride
go.drugbank.com/drugs/DB14045ExperimentalCholesteryl chloride, also known as 3-chlorocholest-5-ene, is an organochloride derivative of cholesterol. It is presented as a liquid crystal that forms clockwise liquid crystals.
Synonyms: 3-Chlorocholest-5-ene, 3-Chlorocholestene