This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Nordazepam is a benzodiazepine indicated in the treatment of insomnia.
- Generic Name
- Nordazepam
- DrugBank Accession Number
- DB14028
- Background
An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Nordazepam (DB14028)
- Weight
- Average: 270.714
Monoisotopic: 270.055990691 - Chemical Formula
- C15H11ClN2O
- Synonyms
- Desmethyldiazepam
- N-desmethyldiazepam
- Nordazepam
- Nordazepam CIV
- Nordazepamum
- Nordiazepam
- External IDs
- A 101
- A101
- RO 5-2180
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
Target Actions Organism AGABA(A) Receptor positive allosteric modulatorHumans AGABA(A) Receptor Benzodiazepine Binding Site ligandHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Nordazepam. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Nordazepam. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Nordazepam. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with Nordazepam. Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Nordazepam. Alimemazine The risk or severity of CNS depression can be increased when Alimemazine is combined with Nordazepam. Almotriptan The risk or severity of CNS depression can be increased when Almotriptan is combined with Nordazepam. Alosetron The risk or severity of CNS depression can be increased when Alosetron is combined with Nordazepam. Alprazolam The risk or severity of CNS depression can be increased when Alprazolam is combined with Nordazepam. Alverine The risk or severity of CNS depression can be increased when Alverine is combined with Nordazepam. 
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- Not Available
Products
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- Calmday / Lomax / Madar / Sopax / Stilny / Vegesan
Categories
- ATC Codes
- N05BA16 — Nordazepam
- Drug Categories
- Amino Acids
- Amino Acids, Aromatic
- Amino Acids, Cyclic
- Amino Acids, Peptides, and Proteins
- Anti-Anxiety Agents
- Benzazepines
- Benzodiazepines and benzodiazepine derivatives
- Benzodiazepinones
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Heterocyclic Compounds, Fused-Ring
- Nervous System
- Neurotransmitter Agents
- Psycholeptics
- Psychotropic Drugs
- Tranquilizing Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzodiazepines
- Sub Class
- 1,4-benzodiazepines
- Direct Parent
- 1,4-benzodiazepines
- Alternative Parents
- Benzene and substituted derivatives / Aryl chlorides / Cyclic carboximidic acids / Ketimines / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organochlorides / Hydrocarbon derivatives
- Substituents
- 1,4-benzodiazepine / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide / Azacycle / Benzenoid / Cyclic carboximidic acid / Hydrocarbon derivative / Imine / Ketimine
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- organochlorine compound, 1,4-benzodiazepinone (CHEBI:111762)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 67220MCM01
- CAS number
- 1088-11-5
- InChI Key
- AKPLHCDWDRPJGD-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
- IUPAC Name
- 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
- SMILES
- ClC1=CC=C2NC(=O)CN=C(C3=CC=CC=C3)C2=C1
References
- General References
- AIFA: Madar (Nordazepam) Oral Tablet [Link]
- External Links
- Human Metabolome Database
- HMDB0060538
- KEGG Drug
- D08283
- KEGG Compound
- C07486
- ChemSpider
- 2890
- BindingDB
- 50027835
- 3155
- ChEBI
- 111762
- ChEMBL
- CHEMBL523
- ZINC
- ZINC000001249069
- Wikipedia
- Nordazepam
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Pill Tablet, coated Tablet Oral 15 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0219 mg/mL ALOGPS logP 2.79 ALOGPS logP 3.21 Chemaxon logS -4.1 ALOGPS pKa (Strongest Acidic) 12.3 Chemaxon pKa (Strongest Basic) 2.85 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 41.46 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 76.7 m3·mol-1 Chemaxon Polarizability 27.41 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Targets
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- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Positive allosteric modulator
- Curator comments
- The GABA(A) receptor is pentameric (i.e. comprising 5 subunit proteins) and therefore has a multitude of potential isoforms. The above target is a collection of all possible GABA(A) subunits that may participate in the formation of the pentameric receptor and is not meant to imply direct a drug-protein interaction for each individual subunit.
- General Function
- Inhibitory extracellular ligand-gated ion channel activity
- Specific Function
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...
Components:
References
- Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4. [Article]
- Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Ligand
- Curator comments
- Benzodiazepines modulate GABA(A) function by binding at the interface between alpha (α) and gamma (γ) subunits. Of the 6 α-subunits, only 4 (α-1, -2, -3, and -5) participate in the formation of this binding site. The above target is a collection of all α- and γ-subunits that are known to participate in the formation of the benzodiazepine binding site.
- General Function
- Inhibitory extracellular ligand-gated ion channel activity
- Specific Function
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...
Components:
References
- Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4. [Article]
- Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27. [Article]
Drug created at May 15, 2018 20:27 / Updated at May 14, 2021 01:06