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Displaying results 951 - 960 of 10000 in total
  1. Drug

    Trestolone acetate

    go.drugbank.com/drugs/DB13958
    Experimental

    Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. … It is an androgen ester – specifically, the C17 acetate ester of [DB05830].

    Synonyms: 17β-Hydroxy-7α-methylestr-4-en-3-one acetate, 17beta-Hydroxy-7alpha-methylestr-4-en-3-one acetate
  2. Drug

    (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R,5S)-2-hydroxy-5-methylcyclopentyl]amino}-5-oxopentyl]-4-{[6-chloro-5-(4-methyl-1-piperazinyl)-2-pyrazinyl]carbonyl}-N-(2-methyl-2-propanyl)-2-piperazineca rboxamide

    go.drugbank.com/drugs/DB02785
    Experimental

    Synonyms: (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R,5S)-2-hydroxy-5-methylcyclopentyl]amino}-5-oxopentyl]-4-{[6-chloro-5-(4-methyl-1-piperazinyl)-2-pyrazinyl]carbonyl}-N-(2-methyl-2-propanyl)-2-piperazineca
  3. Drug

    Deflazacort

    go.drugbank.com/drugs/DB11921
    Approved

    Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). … [A179446,A179449,L6697] This disease usually manifests by muscle weakness in early childhood followed by loss of the ability to walk (ambulation) as early as age 7.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 11.BETA.,21-DIHYDROXY-2'-METHYL-5'.BETA.H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE 21-ACETATE, 5'H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE, 21-(ACETYLOXY)-11-HYDROXY-2'-METHYL-, (11.BETA.,16.BETA.)-
  4. Drug

    Isopropyl myristate

    go.drugbank.com/drugs/DB13966
    Approved

    [A178078] At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse [A32333, L1964, L1966]. … Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption.

    Synonyms: 1-Methylethyl tetradecanoate
  5. Drug

    Azimilide

    go.drugbank.com/drugs/DB04957
    Investigational

    It is not approved for use in any country, but is currently in clinical trials in the United States. … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: 1-((5-(P-CHLOROPHENYL)FURFURYLIDENE)AMINO)-3-(4-(4-METHYL-1-PIPERAZINYL)BUTYL)HYDANTOIN, 2,4-IMIDAZOLIDINEDIONE, 1-(((5-(4-CHLOROPHENYL)-2-FURANYL)METHYLENE)AMINO)-3-(4-(4-METHYL-1-PIPERAZINYL)BUTYL)-
  6. Drug

    Oxcarbazepine

    go.drugbank.com/drugs/DB00776
    ApprovedInvestigational

    [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood … - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine].

    Categories: P-glycoprotein inducers, P-glycoprotein substratesSynonyms: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide
  7. Drug

    Alprenolol

    go.drugbank.com/drugs/DB00866
    ApprovedWithdrawn

    Alprenolol is no longer marketed by AstraZeneca, but may still be available in generic varieties. … One of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

    Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT1A Receptor AntagonistsSynonyms: 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol, (RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol
  8. Drug

    Imipramine

    go.drugbank.com/drugs/DB00458
    ApprovedInvestigational

    TCAs also block histamine H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred … In depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake.

    Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsSynonyms: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
  9. Drug

    Aprobarbital

    go.drugbank.com/drugs/DB01352
    ExperimentalIllicit

    Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. … A primary treatment indicated for the use of aprobarbital was subsequently insomnia.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InducersSynonyms: 5-(1-methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, 5-allyl-5-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione
  10. Drug

    Diamino-N-[(4S)-5-anilino-4-{[(2S)-2-{[(1R)-1-carboxyethyl]amino}-4-phenylbutanoyl]amino}-5-oxopentyl]methaniminium

    go.drugbank.com/drugs/DB02747
    Experimental

    Synonyms: Diamino-N-[(4S)-5-anilino-4-{[(2S)-2-{[(1R)-1-carboxyethyl]amino}-4-phenylbutanoyl]amino}-5-oxopentyl]methaniminium