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SAR443122
go.drugbank.com/drugs/DB16492InvestigationalSAR443122, was investigated in several clinical trials to evaluate its safety and efficacy. … NCT04469621 was studied in severe COVID-19 patients, while NCT05588843 is currently recruiting participants with ulcerative colitis.
Synonyms: 1H-1,2,4-TRIAZOLE-5-CARBOXAMIDE, 3-(PHENYLMETHYL)-N-((3S)-2,3,4,5-TETRAHYDRO-5-METHYL-4-OXOPYRIDO(3,2-B)(1,4)OXAZEPIN-3-YL)-, 3-(PHENYLMETHYL)-N-((3S)-2,3,4,5-TETRAHYDRO-5-METHYL-4-OXOPYRIDO(3,2-B)(1,4)OXAZEPIN-3-YL)-1H-1,2,4-TRIAZOLE-5-CARBOXAMIDEAmmonium molybdate
go.drugbank.com/drugs/DB11128InvestigationalAmmonium molybdate is a source of molybdenum that exists in several hydrate forms. It is intravenously administered as an additive to solutions for Total Parenteral Nutrition (TPN). … Molybdenum is an essential element that is present in enzymes including xanthine oxidase, sulfite oxidase, and aldehyde oxidase.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Molybdenum (as ammonium molybdate)Selisistat
go.drugbank.com/drugs/DB13978InvestigationalEnhances p53 acetylation in response to DNA damaging agents.
Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 3-RingSynonyms: rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamideIsatin
go.drugbank.com/drugs/DB02095ExperimentalThe compound is found in many plants and Schiff bases of Isatin are have been investigated for pharmaceutical applications. … Isatin is an indole derivative first obtained by Erdman and Laurent in 1841 as an oxidation product of Indigo dye with nitric acid and chromic acids.
Categories: Heterocyclic Compounds, 2-RingPimicotinib
go.drugbank.com/drugs/DB18972Investigational[L53748] Pimicotinib was granted Fast Track Designation in December 2023 by the FDA. [L53753] … Pimicotinib is under investigation in clinical trial NCT05804045 (Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-Pyrrolidinecarboxamide, 3,3-dimethyl-N-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-oxo-, 3,3-Dimethyl-N-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-oxo-1-pyrrolidinecarboxamideLomerizine
go.drugbank.com/drugs/DB14065Experimental[A245383] This drug is used to prophylactically treat migraines[A245368, A245373] and is also being investigated against eye-related diseases that are associated with local circulatory disturbances, an … Lomerizine is a diphenylmethylpiperazine calcium channel blocker[A245378, A245383] with relatively selective central nervous system (CNS) effects.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesReproxalap
go.drugbank.com/drugs/DB16688Investigational[L32990] NS-2 has orphan drug status due to it being investigated for treatment of Sjogren-Larsson syndrome.[L32990] … Reproxalap (previously ADX 102 or NS-2) is a small molecule inhibitor being developed by Aldeyra Therapeutics investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis
Categories: Heterocyclic Compounds, 2-RingSynonyms: NS-2AVR-RD-01
go.drugbank.com/drugs/DB17651InvestigationalIt consists of autologous CD34+ cells that transduced with Lentiviral Vector/alpha-galactosidase A (AGA) encoding for the human AGA complementary deoxyribonucleic acid (cDNA) sequence. … AVR-RD-01 is being investigated for Fabry Disease.[L45963, L45968]
VPM4001
go.drugbank.com/drugs/DB05089ExperimentalInterferon-γ enhances presentation of tumour antigens, whereas interleukin-2 stimulates T cells. … It consists of irradiated human LNCaP cells that have been genetically modified to permanently secrete interferon-γ and interleukin-2 (LNCaP/IL-2/IFN-γ).
Pyruvaldehyde
go.drugbank.com/drugs/DB03587ExperimentalIt has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals. [PubChem] … An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning.
Synonyms: 2-oxopropanal, 2-ketopropionaldehyde