Reproxalap
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Reproxalap
- DrugBank Accession Number
- DB16688
- Background
Reproxalap (previously ADX 102 or NS-2) is a small molecule inhibitor being developed by Aldeyra Therapeutics investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjögren-Larsson syndrome.1 NS-2 has orphan drug status due to it being investigated for treatment of Sjogren-Larsson syndrome.1
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 236.7
Monoisotopic: 236.0716407 - Chemical Formula
- C12H13ClN2O
- Synonyms
- ADX 102
- ADX102
- ALD-102
- NS-2
- Reproxalap
- External IDs
- ADX 102
- ADX-102
- ADX102
- ALD-102
- NS 2
- NS-2
- NS2
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Reproxalap inhibits Reactive Aldehyde Species (RASP) and is being investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjögren-Larsson syndrome.1
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- F0GIZ22IJH
- CAS number
- 916056-79-6
- InChI Key
- GUHFUVLKYSQIOQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H13ClN2O/c1-12(2,16)11-9(14)6-7-5-8(13)3-4-10(7)15-11/h3-6,16H,14H2,1-2H3
- IUPAC Name
- 2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol
- SMILES
- CC(C)(O)C1=NC2=C(C=C1N)C=C(Cl)C=C2
References
- General References
- National Center for Advancing Translational Sciences (NCATS): REPROXALAP [Link]
- External Links
- ChemSpider
- 17246660
- ChEMBL
- CHEMBL4297210
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Allergic Conjunctivitis (AC) 3 3 Completed Treatment Dry Eye Syndrome (DES) 1 3 Completed Treatment Dry Eyes 2 3 Completed Treatment Non-Infectious Anterior Uveitis 1 3 Completed Treatment Sjogren-Larsson Syndrome (SLS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.237 mg/mL ALOGPS logP 2.78 ALOGPS logP 2.22 Chemaxon logS -3 ALOGPS pKa (Strongest Acidic) 13.91 Chemaxon pKa (Strongest Basic) 3.32 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 59.14 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 64.99 m3·mol-1 Chemaxon Polarizability 24.71 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0090000000-6b81cf11bef932613890 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-000i-0090000000-444f151b659d38022060 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-000i-1290000000-3dd82c4a69fbcc5188ab Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0gbi-0090000000-3a05720d8c954acb649b Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0fb9-0900000000-1e4a3c4ad66dd6cc80ec Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0f8l-6930000000-ba1c4e92fbc1d67ad57c Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at April 08, 2021 14:48 / Updated at September 12, 2023 18:32