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Belumosudil

go.drugbank.com/drugs/DB16703
ApprovedInvestigational

Belumosudil is used in the treatment of chronic graft-versus-host disease (GVHD) and has been investigated for the treatment of pulmonary arterial hypertension. It is an inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC50...

  1. Drug

    Axatilimab

    go.drugbank.com/drugs/DB16388
    ApprovedInvestigational

    [A264309] Approved treatment options in steroid-refractory cGHVD are limited, and include [ruxolitinib], [ibrutinib], and [belumosudil].