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Displaying all 5 results
  1. Pathway

    Spironolactone Action Pathway

    smpdb.ca/view/SMP0000134
    Drug action

    Aldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … It acts by competing with aldosterone for its receptor inside the principal cells of the late distal tubule and collecting tubule.

    Drugs: Cysteine · Spironolactone · Potassium cation · Urea
    Enzymes: Neutral and basic amino acid transport protein rBAT, Sodium- and chloride-dependent transporter XTRP3
  2. Pathway

    Retinol Metabolism

    smpdb.ca/view/SMP0000074
    Metabolic

    Other forms of vitamin A include retinal, its aldehyde form, retinoic acid, its acid form, and reinyl ester, its ester form. … to either 4-hydroxyretinoic acid or all-trans-18-hydroxyretinoic acid by cytochrome P450 26A1.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
  3. Pathway

    Vitamin A Deficiency

    smpdb.ca/view/SMP0125788
    Disease

    A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. … Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
  4. Pathway

    Vitamin A Deficiency

    smpdb.ca/view/SMP0000336
    Disease

    A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. … Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
  5. Pathway

    Spironolactone Action Pathway (New)

    smpdb.ca/view/SMP0126006
    Drug action

    Some side effects of using spironolactone may include feeling dizzy, experiencing muscle cramps, feeling tired and low in energy, and experiencing breast pain and enlargement. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Spironolactone · Potassium cation · Urea