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  1. Target

    Transient receptor potential cation channel subfamily V member 1

    go.drugbank.com/bio_entities/BE0001023
    TargetHumans

    Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175).

    Synonyms: Capsaicin receptor
  2. Target

    Protein kinase C epsilon type

    go.drugbank.com/bio_entities/BE0003431
    TargetHumans

    Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons.

  3. Target

    Protein kinase C

    go.drugbank.com/bio_entities/BE0004895
    TargetEnzymeHumans

    Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons.