Protein kinase C epsilon type

BE0003431ProteinHumansPRKCE

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth... It is acted on by 5 drugs in DrugBank.

Gene name
PRKCE
UniProtKB entry
Q02156Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
737 residues · 83,673 Da
Also known as
2.7.11.13 · nPKC-epsilon · PKCE

Resolves to

Protein
UniProtQ02156UniProt nameKPCE_HUMAN
Gene
HGNCHGNC:9401NCBI Gene5581GeneCardsPRKCE
Pharmacology
IUPHAR/GtoPdb1486KEGGhsa:5581
Structure
PDB2WH0PDB5LIH
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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27GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein kinase C epsilon type, how selective are they, and which programs against it are still in active trials?

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