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Chloroquine Action Pathway

Chloroquine passively diffuses through cell membranes and into endosomes, lysosomes, and Golgi vesicles; where it becomes protonated, trapping the chloroquine in the organelle and raising the surrounding … Chloroquine inhibits the action of heme polymerase, which causes the buildup of toxic heme in Plasmodium species, preventing the conversion of heme to hemazoin.