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Displaying results 1 - 10 of 310 in total
  1. Drug

    Chloroquine

    go.drugbank.com/drugs/DB00608
    ApprovedInvestigationalVet approved

    [L14312]** Chloroquine was granted FDA Approval on 31 October 1949.[L12054] … Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria.

    Synonyms: Chloroquine, ChloraquineSalts: Chloroquine sulfate, Chloroquine phosphate
  2. Drug

    Ezurpimtrostat

    go.drugbank.com/drugs/DB16458
    Investigational

    Synonyms: Chloroquine analog
  3. Target

    Chloroquine resistance transporter

    go.drugbank.com/bio_entities/BE0009205
    TargetTransporterPlasmodium falciparum

    Nutrient transporter (PubMed:25733858, PubMed:32764664, PubMed:35867395). Substrate transport is pH-dependent (PubMed:25733858, PubMed:37454114). Can transport arginine, lysine, histidine, peptides, histamine and spermidine (PubMed:25733...

    Polypeptides: Chloroquine resistance transporter
  4. Pathway

    Chloroquine Action Pathway

    smpdb.ca/view/SMP0125864
    Drug action

    Chloroquine passively diffuses through cell membranes and into endosomes, lysosomes, and Golgi vesicles; where it becomes protonated, trapping the chloroquine in the organelle and raising the surrounding … Chloroquine inhibits the action of heme polymerase, which causes the buildup of toxic heme in Plasmodium species, preventing the conversion of heme to hemazoin.

    Drugs: ATP · Chloroquine · Mesoheme
  5. Drug

    Chloroxine

    go.drugbank.com/drugs/DB01243
    ApprovedWithdrawn

    Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.

    Synonyms: Chloroxine
  6. Indication

    Chloroquine resistance

    go.drugbank.com/conditions/DBCOND0136056
    Drugs: Mefloquine · Sulfadoxine
    Synonyms: Chloroquine resistance
  7. Drug

    Copper

    go.drugbank.com/drugs/DB09130
    ApprovedInvestigational

    Copper is commonly used in contraceptive intrauterine devices (IUD) [L801]. … Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label].

    Synonyms: cobre, CopperMixtures: Complex, Kamu Jay Multi Complex Tab
  8. Drug

    Prochlorperazine

    go.drugbank.com/drugs/DB00433
    ApprovedInvestigationalVet approved

    Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such a...

    Products: Compro
  9. Drug

    Copper oxodotreotide Cu-64

    go.drugbank.com/drugs/DB15873
    Approved

    [A220348] Further studies should be performed to compare the two tracers. … Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over <sup>68</sup>Ga-labeled somatostatin analogs for positron emission tomography (PET).

    Synonyms: Copper 64-DOTA-tate, Copper Cu-64 dotatateCategories: Copper Radioisotopes
  10. Drug

    Copper histidinate

    go.drugbank.com/drugs/DB32041
    Approved

    [A275383] Copper histidinate is a subcutaneously-administered copper-histidine complex that allows for copper supplementation in patients with defective ATP7A transporters. … in severe systemic copper deficiency.

    Synonyms: Copper histidine, Copper histidinate