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Anti-inhibitor coagulant complex
Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.
Andexanet alfa
go.drugbank.com/drugs/DB14562ApprovedIt also prevents andexanet alfa from taking up space on phospholipid surface membranes, so that native FXa may bind and assemble the prothrominase complex [A35558]. … andexanet alfa is eliminated through the removal of a 34-residue fragment containing Gla: via this truncation, andexanet alfa is unable to bind to membrane surfaces and assemble the prothrombinase complex
Categories: CoagulantsSynonyms: rfXa Inhibitor AntidotePerioperative Bleeding caused by Hemophilia A
go.drugbank.com/conditions/DBCOND0089513Perioperative Bleeding caused by Hemophilia B
go.drugbank.com/conditions/DBCOND0089515Antihemophilic factor human
go.drugbank.com/drugs/DB13192ApprovedInvestigationalThe complex was developed by CSL Behring or Baxter Healthcare Corporation and approved in the 90s. … The small amount of VWF:Ag is used to purify factor VIII complex and then removed from the final preparation. The final purified concentrate contains albumin as a stabilizer.[L1053].
Mixtures: von Willebrand Factor/Coagulation Factor VIII Complex (Human), von Willebrand Factor/Coagulation Factor VIII Complex (Human)Categories: CoagulantsBleeding caused by Hemophilia B
go.drugbank.com/conditions/DBCOND0089514Annexin A5
go.drugbank.com/bio_entities/BE0004149TargetCarrierHumansThis protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade
Synonyms: Thromboplastin inhibitorBleeding caused by Hemophilia A
go.drugbank.com/conditions/DBCOND0089512