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Benralizumab

go.drugbank.com/drugs/DB12023
ApprovedInvestigational

Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils and basophils. It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits...

  1. Indication

    Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) (EGPA)

    go.drugbank.com/conditions/DBCOND0075300
    Drugs: Benralizumab · Mepolizumab
  2. Indication

    Hypereosinophilic Syndrome (HES)

    go.drugbank.com/conditions/DBCOND0131618
    Drugs: Benralizumab · Hydroxyurea · Imatinib · Mepolizumab
  3. Indication

    Severe Eosinophilic Asthma

    go.drugbank.com/conditions/DBCOND0078144
    Drugs: Benralizumab · Mepolizumab · Reslizumab
  4. Drug

    Tezepelumab

    go.drugbank.com/drugs/DB15090
    ApprovedInvestigational

    [A243764, A243769, A243774] As existing asthma treatments such as [omalizumab], [mepolizumab], [reslizumab], [benralizumab], and [dupilumab] act on specific downstream mediators of the inflammatory response