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Bivalirudin

go.drugbank.com/drugs/DB00006
ApprovedInvestigational

Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is importan...

  1. Pathway

    Bivalirudin.

    smpdb.ca/view/SMP0000277
    Drug action

    As a result, bivalirudin prevents or reduces clot formation. … Bivalirudin does not need cofactor antithrobin to act. It binds circulating and clot-bound thrombin at the catalytic site and the anion binding exosite.

    Drugs: Bivalirudin · Phylloquinone · Calcium
    Enzymes: Bivalirudin
  2. Pathway

    Bivalirudin Action Pathway

    smpdb.ca/view/SMP0126441
    Drug action

    Bivalirudin is cleared from plasma by the renal system and proteolytic cleavage. … Bivalirudin is a direct thrombin inhibitor that treats heparin-induced thrombocytopenia and prevents thrombosis.

    Drugs: Bivalirudin · Calcium
  3. Drug

    Argatroban

    go.drugbank.com/drugs/DB00278
    ApprovedInvestigational

    The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary

  4. Drug

    Anivamersen

    go.drugbank.com/drugs/DB16089
    Investigational

    Anivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI).

  5. Indication

    Thrombosis

    go.drugbank.com/conditions/DBCOND0020122
    Drugs: Acetylsalicylic acid · Argatroban · Atorvastatin · Bivalirudin · Dextran · Dipyridamole +2 more