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Linaclotide

go.drugbank.com/drugs/DB08890
ApprovedInvestigational

Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist. Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from Esche...

  1. Indication

    Functional Constipation (FC)

    go.drugbank.com/conditions/DBCOND0153502
    Drugs: Linaclotide
  2. Indication

    Chronic idiopathic constipation (CIC)

    go.drugbank.com/conditions/DBCOND0102972
    Drugs: Lactitol · Linaclotide · Lubiprostone · Plecanatide · Prucalopride
  3. Indication

    Irritable Bowel Syndrome With Constipation (IBS-C)

    go.drugbank.com/conditions/DBCOND0064306
    Drugs: Linaclotide · Lubiprostone · Plecanatide · Tegaserod · Tenapanor