Irritable Bowel Syndrome With Constipation (IBS-C) (DBCOND0064306)

Identifiers

Synonyms
Irritable Bowel Syndrome - Constipation / Irritable Bowel Syndrome (IBS-C) / Irritable Bowel Syndrome-Constipation / IBS, Constipation Predominant / Constipation-predominant IBS (IBS-C) / Constipation-predominant Irritable Bowel Syndrome (IBS-C) / Irritable Bowel Syndrome Constipation Predominant / Irritable Bowel Syndrome Predominant Constipation / Constipation-Predominant Irritable Bowel Syndrome / Constipation Predominant Irritable Bowel Syndrome / Irritable Bowel Syndrome With Constipation / Irritable bowel syndrome characterized by constipation (disorder) / Irritable bowel syndrome without diarrhea / Irritable colon / Colitis mucous / Mucous colitis / Colon spastic / Spastic colon / Irritable colon syndrome / Functional bowel syndrome / Irritable bowel / Irritable bowel syndrome / Irritable colon (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Linaclotide
A guanylate cyclase-C agonist used to treat different types of constipation, such as irritable bowel syndrome-related constipation, idiopathic constipation, and functional constipation.
Lubiprostone
A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
Plecanatide
A laxative used to treat chronic idiopathic constipation and IBS with constipation.
Tegaserod
A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
Tenapanor
An NHE3 inhibitor indicated for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic kidney disease,
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05157061
GOS to Reduce Symptom Severity in IBSNo drug interventionstreatmentNot Availablerecruiting
NCT00171431
The Effect of Tegaserod on Patterns of Flow in the Small Bowel of Patients With Irritable Bowel Syndrome (IBS)treatment3terminated
NCT00584571
SAT vs Escitalopram for Rectal Hypersensitivitytreatment2completed
NCT00619125
Proposal Evaluating Time-specific Relationships Between Variables of Pain, Stress, and Bloating in IBS Diarrhea and Constipation Symptoms Using a Palm PilotNo drug interventionsNot AvailableNot Availablecompleted
NCT05240521
Efficacy and Safety, Tolerability of GA-AT0119 in IBS-CNo drug interventionstreatmentNot Availableunknown_status
NCT06553547
4-Week, Multi-Center, Randomized, Db-Blind, Placebo-Controlled, Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrstreatment2recruiting
NCT03471728
Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases)Not AvailableNot Availablecompleted
NCT05643534
Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Yearstreatment3recruiting
NCT02495623
A Study of the Effect of SYN-010 on Subjects With IBS-CNo drug interventionstreatment2completed
NCT02316899
Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrometreatment3completed
NCT02493036
A Single-Dose, Open-Label, Study to Evaluate the Sustainability of the Effects of SYN-010 in Patients With IBS-CNo drug interventionstreatment2completed
NCT01880424
A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)treatment3completed
NCT05905926
Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-Chealth_services_research3enrolling_by_invitation
NCT02078323
Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C PatientsotherNot Availablecompleted
NCT02144753
Use of Novel Prebiotic Fiber for Targeted Dietary Management of Irritable Bowel Syndrome (Nutrabiotix Phase II)supportive_care2terminated
NCT01714843
A Study to Evaluate the Effect of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrometreatment2completed
NCT01056107
Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) PatientsNo drug interventionstreatment1 / 2completed
NCT02559245
Effect of Flixweed and Fig on Irritable Bowel Syndrome With Predominant Constipation: a Single Blind Randomized Clinical Trial.No drug interventionstreatmentNot Availablecompleted
NCT02727751
A Long-Term Safety Study of Tenapanor for the Treatment of IBS-Ctreatment3completed
NCT01340053
A Study to Evaluate the Safety and Efficacy of RDX5791 for the Treatment of Constipation Predominant Irritable Bowel Syndrome (IBS-C)No drug interventionstreatment2completed
NCT05321953
The Impact of Aerobic Interval and Inspiratory Muscle Training On Patient Reported Outcome Scores In Individuals With Chronic ConstipationNo drug interventionstreatmentNot Availablewithdrawn
NCT05921383
Anorectal Manometry of Patients With Constipation Predominant IBSNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00607971
Long-Term Safety of Renzapride in Women With Constipation-Predominant Irritable Bowel Syndrome (IBS-C)Not Available3terminated
NCT05757037
Laser Acupuncture on Irritable Bowel Syndrome in FemalesNo drug interventionstreatmentNot Availablerecruiting
NCT03336034
Assessment of Responsiveness to Treatment by Experience Sampling MethodNo drug interventionsNot AvailableNot Availableterminated
NCT05392439
Effect of taVNS on Abdominal Pain and Other Symptoms in Constipation-predominant Irritable Bowel SyndromeNo drug interventionstreatmentNot Availablecompleted
NCT01923428
The Efficacy of AZD1722 in Constipation Predominant Irritable Bowel Syndrome (IBS-C)treatment2 / 3completed
NCT00742872
Randomized Trial of Mosapride Versus Placebo in the Treatment of Constipation-Predominant Irritable Bowel Syndrometreatment3terminated
NCT03150212
Effect of Saccharomyces Cerevisiae on the Improvement of Gastro-intestinal Disorders Associated to IBS With C PhenotypeNo drug interventionstreatmentNot Availablecompleted
NCT05941650
To Study the Effect of Short-chain Fructooligosaccharides in Women With Irritable Bowel SyndromeNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01085643
Effect of Lubiprostone on Small Bowel Contractions in Female Patients With Constipation Irritable Bowel Syndrome (C-IBS)basic_scienceNot Availablecompleted
NCT05134584
Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal Disorderstreatment4unknown_status
NCT05164861
Safety and Efficacy of Non-alcoholic Beverage Based on Kombucha in Patients With ConstipationsNo drug interventionstreatmentNot Availablecompleted
NCT02686138
A 26-Week Study to Evaluate the Efficacy and Safety of Tenapanor in IBS-Ctreatment3completed
NCT02621892
A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-Ctreatment3completed
NCT00945334
Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel SyndrometreatmentNot Availablecompleted
NCT06319729
A Chinese Herbal Medicine for IBS-CNo drug interventionstreatment2not_yet_recruiting
NCT00912301
Cheno Effect on Transit in Health and IBS-Ctreatment2completed
NCT04666155
MOWOOT Device Treatment for Adults With Chronic ConstipationNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03596905
Efficacy and Safety of Plecanatide in Children 6 to <18 Years of Age With Irritable Bowel Syndrome With Constipation (IBS-C)treatment2recruiting
NCT05519683
Home Transcutaneous Electrical Acustimulation (TEA)treatment2 / 3recruiting
NCT00511771
A Treatment Investigational New Drug (tIND) Program of Tegaserod in Women With Irritable Bowel Syndrome With Constipation or With Chronic Idiopathic ConstipationNot AvailableNot Availableno_longer_available
NCT04968652
IBS-C Questionnaire StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03763175
Efficacy and Safety of SYN-010 in IBS-Ctreatment2terminated
NCT04214470
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in IBSNo drug interventionsNot AvailableNot Availableunknown_status
NCT00765999
An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipationtreatment3completed
NCT02559817
A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipationtreatment2terminated
NCT04166058
Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-CNo drug interventionstreatment3active_not_recruiting
NCT04997057
A Multistrain Probiotic in Patients With Irritable Bowel Syndrome With Predominant ConstipationNo drug interventionstreatmentNot Availablecompleted
NCT04647045
An Evaluation of Cultured Milk Drink on Immune Status of Patients With Irritable Bowel Syndrome: Constipation PredominantNo drug interventionsbasic_scienceNot Availablecompleted
NCT00460811
Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)treatment2completed
NCT00730171
An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipationtreatment3completed
NCT05796388
A Study of Virtual Reality and Linaclotide for IBS-CNo drug interventionstreatmentNot Availablerecruiting
NCT06219707
Electro-acupuncture for Irritable Bowel Syndrome With ConstipationNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02590432
An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipationtreatment4completed
NCT03054506
The Effect of CSP01 on Chronic Idiopathic Constipation and Irritable Bowel Syndrome With ConstipationNo drug interventionstreatmentNot Availablecompleted
NCT02559206
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)treatment2completed
NCT04026113
Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)treatment3completed
NCT00938717
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)No drug interventionstreatment3completed
NCT05646186
Personalized Dietary Intervention Based on Microbiome Analysis vs FODMAP Diet for Irritable Bowel SyndromeNo drug interventionstreatmentNot Availableunknown_status
NCT00215566
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-ctreatment2completed
NCT04484467
Efficacy and Safety of a Food Supplement With Standardized Menthol, Limonene, and Gingerol Content in Patients With Irritable Bowel SyndromeNo drug interventionstreatmentNot Availablecompleted
NCT04132804
Effect of Tai Chi as Treatment for IBS-CNo drug interventionstreatmentNot Availablecompleted
NCT00380250
Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipationtreatment3completed