Displaying drugs 10776 - 10800 of 12647 in total
Pafuramidine
Pafuramidine, a prodrug of furamidine, currently has orphan status for Pneumocystis jiroveci pneumonia.
Investigational
Matched Description: … Pafuramidine, a prodrug of furamidine, currently has orphan status for _Pneumocystis jiroveci_ pneumonia …
Omiganan
Omiganan has been investigated for the treatment of Mupirocin-resistant MRSA skin infections.
Investigational
Matched Description: … Omiganan has been investigated for the treatment of Mupirocin-resistant MRSA skin infections. …
Henagliflozin
Henagliflozin has been used in trials studying the treatment of Type 2 Diabetes.
Investigational
Matched Description: … Henagliflozin has been used in trials studying the treatment of Type 2 Diabetes. …
Solnatide
Solnatide has been used in trials studying the treatment of Acute Lung Injury.
Investigational
Matched Description: … Solnatide has been used in trials studying the treatment of Acute Lung Injury. …
Apaziquone
Apaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms.
Investigational
Matched Description: … Apaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms. …
Cenerimod
Cenerimod has been used in trials studying the treatment of Systemic Lupus Erythematosus.
Investigational
Matched Description: … Cenerimod has been used in trials studying the treatment of Systemic Lupus Erythematosus. …
Abituzumab
Abituzumab has been used in trials studying the treatment of Prostate Cancer Metastatic.
Investigational
Matched Description: … Abituzumab has been used in trials studying the treatment of Prostate Cancer Metastatic. …
Pancreatic Polypeptide
Pancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1.
Investigational
Matched Description: … Pancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1. …
Reproterol
Reproterol has been used in trials studying the treatment of Asthma, Exercise-Induced.
Investigational
Matched Description: … Reproterol has been used in trials studying the treatment of Asthma, Exercise-Induced. …
Omigapil
Omigapil has been used in trials studying the treatment of Congenital Muscular Dystrophy.
Investigational
Matched Description: … Omigapil has been used in trials studying the treatment of Congenital Muscular Dystrophy. …
GSK-1521498
GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism.
Investigational
Matched Description: … GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism. …
Torapsel
Torapsel has been used in trials studying the prevention of Ischemia Reperfusion Injury.
Investigational
Matched Description: … Torapsel has been used in trials studying the prevention of Ischemia Reperfusion Injury. …
S65487
S65487 a potent and selective BCL-2 inhibitor, and a prodrug of S55746.
Investigational
Matched Description: … S65487 a potent and selective BCL-2 inhibitor, and a prodrug of S55746. …
VG161
VG161 is an oncolytic virus therapy under investigation for the treatment of cholangiocarcinoma.
Investigational
Matched Description: … VG161 is an oncolytic virus therapy under investigation for the treatment of cholangiocarcinoma. …
DG041
DG041 is a novel, first-in-class, orally-administered small molecule developmented for the prevention of arterial thrombosis and its complications.
DG041, an anti-platelet compound, has shown to be a selective and potent antagonist of the EP3 receptor for prostaglandins E2. EP3 is a target that associates with increased risk of various vascular...
Investigational
Matched Description: … EP3 is a target that associates with increased risk of various vascular diseases. ... DG041 is a novel, first-in-class, orally-administered small molecule developmented for the prevention of ... DG041, an anti-platelet compound, has shown to be a selective and potent antagonist of the EP3 receptor …
ILY101
ILY101 is a metal-free, non-absorbed polymeric drug designed for the selective binding and removal of phosphate anions from the gastrointestinal tract. ILY101 is being developed for the treatment of hyperphosphatemia in CKD patients on dialysis and works by reducing the systemic absorption of dietary phosphate. ILY101 is designed to allow...
Investigational
Matched Description: … by reducing the systemic absorption of dietary phosphate. ... ILY101 is a metal-free, non-absorbed polymeric drug designed for the selective binding and removal of ... ILY101 is being developed for the treatment of hyperphosphatemia in CKD patients on dialysis and works …
LCP-AtorFen
LCP-AtorFen is a fixed-dose combination therapy for the treatment of high cholesterol levels combining atorvastatin (the active ingredient of Lipitor®) and the lowest dose of fenofibrate without food effect. LCP-AtorFen is designed to be a once daily tablet offering a powerful and safe treatment of high cholesterol levels, addressing three...
Investigational
Matched Description: … atorvastatin (the active ingredient of Lipitor®) and the lowest dose of fenofibrate without food effect ... LCP-AtorFen is a fixed-dose combination therapy for the treatment of high cholesterol levels combining ... LCP-AtorFen is designed to be a once daily tablet offering a powerful and safe treatment of high cholesterol …
MB07811
MB07811 is the first of a novel class of product candidates discovered by Metabasis designed to lower serum cholesterol and triglycerides. MB07811, a small molecule that is administered orally, has been extensively studied preclinically and is currently undergoing clinical testing. MB07811 combines a novel thyroid hormone receptor agonist with the...
Investigational
Matched Description: … MB07811 is the first of a novel class of product candidates discovered by Metabasis designed to lower ... The combination of selectivity for the beta form of the receptor, liver targeting and other structural ... is designed to provide significant efficacy while avoiding side effects associated with activation of …
Tunicamycin
Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis in eukaryotes. Tunicamycin blocks...
Experimental
Matched Description: … HexNAc-1-P family of enzymes. ... of glycoprotein synthesis in eukaryotes. ... Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P …
Tesevatinib
Tesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases, Esophageal Cancer, and Leptomeningeal Metastases, among others.
Tesevatinib is a potent inhibitor of multiple RTKs implicated in driving tumor cell proliferation and tumor vascularization (blood vessel formation). Tesevatinib inhibits the EGF, HER2, and VEGF RTKs,...
Investigational
Matched Description: … Tesevatinib inhibits the EGF, HER2, and VEGF RTKs, each of which is a target of currently approved cancer ... demonstrated potent inhibition of tumor growth and causes tumor regression. ... Tesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases …
αAβ–Gas6
αAβ–Gas6 is a chimeric fusion protein being investigated in preclinical studies as an immunotherapeutic agent for Alzheimer's disease (AD). It is made of a single chain variable fragment (scFv) of an Amyloid β (Aβ)-targeting monoclonal antibody fused with a truncated receptor binding domain of growth arrest-specific 6 (Gas6), which is...
Experimental
Matched Description: … It is made of a single chain variable fragment (scFv) of an Amyloid β (Aβ)-targeting monoclonal antibody ... [A253203,A253208] αAβ–Gas6 is a phagocyte inducer of Aβ,[A253203] which is the main component of the ... fused with a truncated receptor binding domain of growth arrest-specific 6 (Gas6), which is a ligand …
R450
R450 is an alpha 1 antagonist that acts to tighten the muscle tone in the bladder. It is being considered for treatment of stress-related urinary incontinence. Phase IIa data for the drug show it reduced the number of incontinent episodes compared to placebo with minimal cardiovascular effects.
Investigational
Matched Description: … It is being considered for treatment of stress-related urinary incontinence. ... Phase IIa data for the drug show it reduced the number of incontinent episodes compared to placebo with …
GPI-0100
GPI-0100 is Avantogen’s lead adjuvanat-immunopotentiator, a key component of vaccines for boosting the immune response.
The GPI-0100 adjuvant, which has been shown to significantly enhance the immune response with a variety of vaccines, has been shown to have good overall performance characteristics on safety and efficacy.
Investigational
Matched Description: … GPI-0100 is Avantogen’s lead adjuvanat-immunopotentiator, a key component of vaccines for boosting the ... GPI-0100 adjuvant, which has been shown to significantly enhance the immune response with a variety of …
Mitometh
Mitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal Carcinoma, Non-small Cell Lung Cancer, and Stage IV Non-small Cell Lung Cancer, among others. Mitometh has been investigated for the treatment of Lung Neoplasms, Untreated Childhood Medulloblastoma, and Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor.
Investigational
Matched Description: … Mitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal ... Mitometh has been investigated for the treatment of Lung Neoplasms, Untreated Childhood Medulloblastoma …
Devafidugene civaparvovec
Devafidugene civaparvovec is an investigational in vivo genome editing product. It uses proprietary zinc finger nucleases (ZFN) that insert a functional copy of the alpha-L-iduronidase (IDUA) enzyme. Developed by Sangamo Therapeutics, Inc., devafidugene civaparvovec is being investigated for the treatment of mucopolysaccharidosis Type I (MPS I).
Experimental
Matched Description: … It uses proprietary zinc finger nucleases (ZFN) that insert a functional copy of the alpha-L-iduronidase ... Developed by Sangamo Therapeutics, Inc., devafidugene civaparvovec is being investigated for the treatment of …
Displaying drugs 10776 - 10800 of 12647 in total