Piperazine is a medication used to treat roundworm and pinworm. Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms.
- Mechanism
- Curator reviewed
Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
- Primary indication
- Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm).Curator reviewed · 2 structured indications
- Formula / weight
- C4H10N2 · 86.1356 g/mol (avg)
- First approval
- Canada, 2000
- Also known as
- Diethylenediamine · Piperazidine
- Code names
- FEMA NO. 4250 · P02CB01
Resolves to
Clinical / RWD
Structure
InChIKey
GLUUGHFHXGJENI-UHFFFAOYSA-NSMILESC1CNCCN1Targets
What you can answer from here — as of September 16, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Piperazine, and which of those have an active Phase 3 trial?
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