- Antiparasitic Agents
- Accession Number
Drugs used to treat or prevent parasitic infections.
Drug Drug Description Ivermectin An anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. Pyrimethamine An antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. Dapsone A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Doxycycline A tetracycline antibiotic used to treat a wide variety of bacterial infections. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Nitazoxanide A thiazolide anti-infective used to treat infections by protozoa, helminths, anaerobic bacteria, microaerophilic bacteria, and viruses. Albendazole A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. Piperazine A medication used to treat roundworm and pinworm. Amodiaquine An antimalarial drug. Furazolidone A drug for the treatment of infectious diarrhea. Mebendazole A benzimidazole anthelmintic used to treat helminth infections. Sulfametopyrazine An antibiotic used in the treatment or prevention of bacterial infections and malaria. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Diethylcarbamazine An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. Thiabendazole A benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. Pentamidine An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. Levamisole Levamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Tinidazole A nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis. Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Praziquantel An anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis. Primaquine An antimalarial indicated to prevent relapse of vivax malaria. Oxamniquine For treatment of Schistosomiasis caused by Schistosoma mansoni Atovaquone An antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. Proguanil A medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria. Halofantrine An antimalarial used for the treatment of severe malaria. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Sulfadoxine A long acting sulfonamide used for the treatment or prevention of malaria. Paromomycin An aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... 5'-S-methyl-5'-thioadenosine Not Available Fumagillin Not Available Benzimidazole Not Available Diminazene Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a... Radicicol Not Available Salicylhydroxamic Acid Not Available Geneticin Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both... Bithionol Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... Halofuginone For the treatment of scleroderma, cancer, and restenosis. Oxibendazole Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications. Lucanthone Intended for use as a radiation sensitizer in the treatment of brain cancer. Andrographolide Investigated for use/treatment in ulcerative colitis. Spiramycin A macrolide antimicrobial agent used in the treatment of various bacterial infections. Eflornithine A medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin. Lonidamine Investigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified). Tafenoquine An antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria. Lumefantrine An antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Niclosamide An anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children. Pyrvinium An anthelmintic agent used for the treatment of pinworm infestations. Anisomycin Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis. Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Diloxanide Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with... Flubendazole Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Miltefosine An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type. Chlortetracycline The first tetracycline antibiotic most commonly used for veterinary purposes. Diiodohydroxyquinoline Used in the treatment of amoebiasis. Artesunate Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Pyrantel An anthelmintic used to treat helminth infections. Hexylresorcinol An ingredient used to relieve irritation, pain, and prevent infection. Amprolium Amprolium is a coccidiostat used in poultry. Cambendazole Not Annotated Clorsulon Not Annotated Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Decoquinate Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites. Dichlorophen Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from... Dichlorvos Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products... Diclazuril Diclazuril is a coccidiostat. Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Eprinomectin Not Annotated Febantel Not Annotated Fenbendazole Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,... Lasalocid Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Moxidectin Moxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and... Narasin Narasin is an agent with coccidiostatic and antibacterial properties. Nicarbazin Not Annotated Oxfendazole Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn. Phenothiazine Phenothiazine (PTZ) is an organic thiazine compound. Roxarsone Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of... Selamectin Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in... Sulfaquinoxaline Sulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K... Metrifonate Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate. Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. Bunamidine Bunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations. Dithiazanine Dithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was... Hygromycin B Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. Imidocarb Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites. Milbemycin oxime Not Annotated Robenidine Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites. Robenidine is used to control coccidiosis, a lethal infection in poultry which... Salinomycin Not Annotated Artenimol For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941. Misonidazole Misonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole). Nifurtimox An antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection). Benznidazole A trypanocidal agent used to treat Chagas disease. Nimorazole Nimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others. Triclabendazole An anthelmintic drug used to treat fascioliasis. Chlorproguanil Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide. Oltipraz Oltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease. Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Secnidazole A nitroimidazole antibiotic used to treat bacterial vaginosis. Melarsoprol Melarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis). Pyronaridine A benzonaphthyridine derivative indicated in the treatment of acute malaria caused by P. falciparum or P. vivax in area with low rates of infection and low resistance to artemisinin. Carbendazim Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific. Ornidazole A nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis. Etofamide Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued . Propamidine Not Annotated Mepartricin A medication indicated in the treatment of benign prostatic hyperplasia, vaginal candidiasis, or trichomoniasis. Niridazole Not Annotated Oxantel An antihelminthic indicated in the treatment of ascaris, trichocephaliasis, and oxyuriasis infections. Nifuratel A nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections. Meglumine antimoniate Not Annotated Albendazole oxide Not Annotated Piperaquine For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638. Stibophen Stibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms. Bephenium Not Annotated Ciclobendazole Not Annotated Desaspidin Not Annotated Hachimycin Not Annotated Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Quinacrine For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. Suramin For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. Sodium stibogluconate For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment... Artemether An antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Chloroxylenol An antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner. Emetine Not Annotated Artemotil Artemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria... Hycanthone Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used. Tetrandrine Not Annotated Diloxanide furoate Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with... Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Cycloguanil Cycloguanil is the active metabolite of proguanil. Pafuramidine Investigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified). Emodepside Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the... Artefenomel Artefenomel has been investigated for the treatment of Malaria. Antimony potassium tartrate Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. Homidium Homidium is a group II compound with trypanocidal effects. Plumbagin Plumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways.
- Drugs & Drug Targets