Anthelmintics

Name
Anthelmintics
Accession Number
DBCAT000944
Description

Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.

ATC Classification
Drugs
DrugDrug Description
AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
PiperazineA medication used to treat roundworm and pinworm.
MebendazoleA benzimidazole anthelmintic used to treat helminth infections.
DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
ThiabendazoleA benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
LevamisoleLevamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections.
PraziquantelAn anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis.
OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...
NiclosamideFor the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used...
PyrviniumAn anthelmintic agent used for the treatment of pinworm infestations.
FlubendazoleFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
PyrantelAn anthelmintic used to treat helminth infections.
FenbendazoleFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,...
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
TriclabendazoleAn anthelmintic drug used to treat fascioliasis.
DichlorophenDichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from...
NiridazoleNot Annotated
OxantelNot Annotated
OxibendazoleInvestigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.
HexylresorcinolAn ingredient used to relieve irritation, pain, and prevent infection.
CambendazoleNot Annotated
ClorsulonNot Annotated
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
EprinomectinNot Annotated
FebantelNot Annotated
MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...
OxfendazoleOxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.
BunamidineBunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations.
DithiazanineNot Annotated
Hygromycin BHygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.
OltiprazOltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease.
CarbendazimCarbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.
Albendazole oxideNot Annotated
StibophenStibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms.
BepheniumNot Annotated
CiclobendazoleNot Annotated
DesaspidinNot Annotated
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.
BenzimidazoleNot Available
HycanthonePotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Antimony potassium tartrateAntimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
Drugs & Drug Targets
DrugTargetType
AlbendazoleTubulin alpha-1A chaintarget
AlbendazoleTubulin beta-4B chaintarget
AlbendazoleCytochrome P450 3A4enzyme
AlbendazoleFumarate reductase flavoprotein subunittarget
AlbendazoleCytochrome P450 1A1enzyme
AlbendazoleCytochrome P450 1A2enzyme
AlbendazoleTubulin beta-2 chaintarget
AlbendazoleCytochrome P450 2C19enzyme
AlbendazoleP-glycoprotein 1transporter
PiperazineGamma-aminobutyric acid receptor subunit beta-3target
PiperazineCytochrome P450 2D6enzyme
MebendazoleTubulin alpha-1A chaintarget
MebendazoleTubulin beta-4B chaintarget
MebendazoleCytochrome P450 1A1enzyme
MebendazoleCytochrome P450 3A Subfamilyenzyme
DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DiethylcarbamazineProstaglandin G/H synthase 1target
DiethylcarbamazineCholinesteraseenzyme
ThiabendazoleFumarate reductase flavoprotein subunittarget
ThiabendazoleCytochrome P450 1A2enzyme
ThiabendazoleCytochrome P450 1A1enzyme
LevamisoleNeuronal acetylcholine receptor subunit alpha-3target
LevamisoleAlkaline phosphatase, placental-liketarget
LevamisoleAcetylcholine receptor subunit alpha-type unc-38target
LevamisoleAcetylcholine receptor subunit alpha-type unc-63target
LevamisoleAcetylcholine receptor subunit beta-type lev-1target
LevamisoleAcetylcholine receptor subunit beta-type unc-29target
PraziquantelSchistosome calcium ion (Ca2+) channelstarget
PraziquantelCytochrome P450 3A4enzyme
PraziquantelCytochrome P450 1A2enzyme
PraziquantelCytochrome P450 2C19enzyme
PraziquantelCytochrome P450 3A43enzyme
PraziquantelCytochrome P450 3A5enzyme
PraziquantelCytochrome P450 3A7enzyme
OxamniquineDNAtarget
OxamniquineCytochrome P450 2D6enzyme
NiclosamideDNAtarget
NiclosamideCytochrome P450 2C9enzyme
NiclosamideCytochrome P450 1A2enzyme
PyrantelG-protein coupled receptor 35target
PyrantelCytochrome P450 4A11enzyme
PyrantelMuscarinic acetylcholine receptor M1target
TriclabendazoleCytochrome P450 1A2enzyme
TriclabendazoleCytochrome P450 2C9enzyme
TriclabendazoleExcretory Secretory (ES) proteinstarget
TriclabendazoleCytochrome P450 3A4enzyme
TriclabendazoleCytochrome P450 1A1enzyme
TriclabendazoleCytochrome P450 1B1enzyme
TriclabendazoleCytochrome P450 2C19enzyme
TriclabendazoleCytochrome P450 2D6enzyme
TriclabendazoleCytochrome P450 2A6enzyme
TriclabendazoleCytochrome P450 2C8enzyme
TriclabendazoleCytochrome P450 2B6enzyme
OxibendazoleTubulin beta-4B chaintarget
HexylresorcinolDNA topoisomerase 1target
HexylresorcinolProtein-glutamine gamma-glutamyltransferase 2target
HexylresorcinolTyrosinasetarget
DichlorvosSerum albumincarrier
DichlorvosSerotransferrintarget
DichlorvosCholinesterasetarget
DoramectinCytochrome P450 3A4enzyme
EprinomectinCytochrome P450 3A4enzyme
MoxidectinCYP2B proteinenzyme
MoxidectinGlutamate-gated chloride channeltarget
MoxidectinGABA-A gated chloride channeltarget
MoxidectinABC transporterstarget
IvermectinGamma-aminobutyric acid receptor subunit beta-3target
IvermectinGlycine receptor subunit alpha-3target
IvermectinP-glycoprotein 1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinCanalicular multispecific organic anion transporter 1transporter
IvermectinATP-binding cassette sub-family G member 2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
LucanthoneDNA topoisomerase 2-alphatarget
LucanthoneDNA-(apurinic or apyrimidinic site) lyasetarget
LucanthoneDNAtarget
LucanthoneDNA topoisomerase 1target
BenzimidazoleNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
HycanthoneP-glycoprotein 1target
HycanthoneP-glycoprotein 1transporter
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier