Amoxicillin is a penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections. Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.
- Mechanism
- Curator reviewed · 5 references
Amoxicillin competitively inhibits penicillin-binding protein 1 and other high molecular weight penicillin binding proteins. Penicillin bind proteins are responsible for glycosyltransferase and transpeptidase reactions that lead to cross-linking of D-alanine and D-aspartic acid in bacterial cell walls. Without the action of penicillin binding proteins, bacteria upregulate autolytic enzymes and are unable to build and repair the cell wall, leading to bacteriocidal action.
- Primary indication
- Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract.Curator reviewed · 35 structured indications
- Formula / weight
- C16H19N3O5S · 365.404 g/mol (avg)
- First approval
- Canada, 1996 · United States, 1978
- Also known as
- Amox · Amoxycillin · p-Hydroxyampicillin
- Code names
- NSC-277174
- Brand names
Resolves to
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Which drugs share a target with Amoxicillin, and which of those have an active Phase 3 trial?
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