Solute carrier family 22 member 6
Details
- Name
- Solute carrier family 22 member 6
- Kind
- protein
- Synonyms
- hOAT1
- hPAHT
- hROAT1
- OAT1
- Organic anion transporter 1
- PAH transporter
- PAHT
- Renal organic anion transporter 1
- Gene Name
- SLC22A6
- UniProtKB Entry
- Q4U2R8Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037120|Solute carrier family 22 member 6 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT RQQQEHQKYMVPLQASAQEKNGL
- Number of residues
- 563
- Molecular Weight
- 61815.78
- Theoretical pI
- 8.78
- GO Classification
- Functionsalpha-ketoglutarate transmembrane transporter activity / antiporter activity / identical protein binding / prostaglandin transmembrane transporter activity / solute / transmembrane transporter activity / xenobiotic transmembrane transporter activityProcessesmetanephric proximal tubule development / monoatomic anion transport / prostaglandin transport / response to organic cyclic compoundComponentsbasal plasma membrane / protein-containing complex
- General Function
- Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:11669456, PubMed:11907186, PubMed:14675047, PubMed:22108572, PubMed:23832370, PubMed:28534121, PubMed:9950961). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (PubMed:9887087). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:11907186). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:26377792). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:22108572, PubMed:23832370). May transport glutamate (PubMed:26377792). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:11669456, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate (PubMed:14675047, PubMed:26377792). Xenobiotics include the mycotoxin ochratoxin (OTA) (PubMed:11669456). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (PubMed:35307651)
- Specific Function
- alpha-ketoglutarate transmembrane transporter activity
- Pfam Domain Function
- Sugar_tr (PF00083)
- Signal Regions
- Not Available
- Transmembrane Regions
- 10-30 136-156 165-187 191-213 225-245 249-269 338-358 369-389 396-416 426-446 456-475 485-505
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0010747|Solute carrier family 22 member 6 (SLC22A6) ATGGCCTTTAATGACCTCCTGCAGCAGGTGGGGGGTGTCGGCCGCTTCCAGCAGATCCAG GTCACCCTGGTGGTCCTCCCCCTGCTCCTGATGGCTTCTCACAACACCCTGCAGAACTTC ACTGCTGCCATCCCTACCCACCACTGCCGCCCGCCTGCCGATGCCAACCTCAGCAAGAAC GGGGGGCTGGAGGTCTGGCTGCCCCGGGACAGGCAGGGGCAGCCTGAGTCCTGCCTCCGC TTCACCTCCCCGCAGTGGGGACTGCCCTTTCTCAATGGCACAGAAGCCAATGGCACAGGG GCCACAGAGCCCTGCACCGATGGCTGGATCTATGACAACAGCACCTTCCCATCTACCATC GTGACTGAGTGGGACCTTGTGTGCTCTCACAGGGCCCTACGCCAGCTGGCCCAGTCCTTG TACATGGTGGGGGTGCTGCTCGGAGCCATGGTGTTCGGCTACCTTGCAGACAGGCTAGGC CGCCGGAAGGTACTCATCTTGAACTACCTGCAGACAGCTGTGTCAGGGACCTGCGCAGCC TTCGCACCCAACTTCCCCATCTACTGCGCCTTCCGGCTCCTCTCGGGCATGGCTCTGGCT GGCATCTCCCTCAACTGCATGACACTGAATGTGGAGTGGATGCCCATTCACACACGGGCC TGCGTGGGCACCTTGATTGGCTATGTCTACAGCCTGGGCCAGTTCCTCCTGGCTGGTGTG GCCTACGCTGTGCCCCACTGGCGCCACCTGCAGCTACTGGTCTCTGCGCCTTTTTTTGCC TTCTTCATCTACTCCTGGTTCTTCATTGAGTCGGCCCGCTGGCACTCCTCCTCCGGGAGG CTGGACCTCACCCTGAGGGCCCTGCAGAGAGTCGCCCGGATCAATGGGAAGCGGGAAGAA GGAGCCAAATTGAGTATGGAGGTACTCCGGGCCAGTCTGCAGAAGGAGCTGACCATGGGC AAAGGCCAGGCATCGGCCATGGAGCTGCTGCGCTGCCCCACCCTCCGCCACCTCTTCCTC TGCCTCTCCATGCTGTGGTTTGCCACTAGCTTTGCATACTATGGGCTGGTCATGGACCTG CAGGGCTTTGGAGTCAGCATCTACCTAATCCAGGTGATCTTTGGTGCTGTGGACCTGCCT GCCAAGCTTGTGGGCTTCCTTGTCATCAACTCCCTGGGTCGCCGGCCTGCCCAGATGGCT GCACTGCTGCTGGCAGGCATCTGCATCCTGCTCAATGGGGTGATACCCCAGGACCAGTCC ATTGTCCGAACCTCTCTTGCTGTGCTGGGGAAGGGTTGTCTGGCTGCCTCCTTCAACTGC ATCTTCCTGTATACTGGGGAACTGTATCCCACAATGATCCGGCAGACAGGCATGGGAATG GGCAGCACCATGGCCCGAGTGGGCAGCATCGTGAGCCCACTGGTGAGCATGACTGCCGAG CTCTACCCCTCCATGCCTCTCTTCATCTACGGTGCTGTTCCTGTGGCCGCCAGCGCTGTC ACTGTCCTCCTGCCAGAGACCCTGGGCCAGCCACTGCCAGACACGGTGCAGGACCTGGAG AGCAGGTGGGCCCCCACTCAGAAAGAAGCAGGGATATATCCCAGGAAAGGGAAACAGACG CGACAGCAACAAGAGCACCAGAAGTATATGGTCCCACTGCAGGCCTCAGCACAAGAGAAG AATGGACTCTGA
- Chromosome Location
- 11
- Locus
- 11q12.3
- External Identifiers
Resource Link UniProtKB ID Q4U2R8 UniProtKB Entry Name S22A6_HUMAN GenBank Protein ID 3831566 GenBank Gene ID AF057039 GeneCard ID SLC22A6 GenAtlas ID hROAT1 HGNC ID HGNC:10970 KEGG ID hsa:9356 IUPHAR/Guide To Pharmacology ID 1025 NCBI Gene ID 9356 - General References
- Reid G, Wolff NA, Dautzenberg FM, Burckhardt G: Cloning of a human renal p-aminohippurate transporter, hROAT1. Kidney Blood Press Res. 1998;21(2-4):233-7. [Article]
- Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 Jan;276(1 Pt 2):F122-8. [Article]
- Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. [Article]
- Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [Article]
- Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999 Sep;56(3):570-80. [Article]
- Bahn A, Prawitt D, Buttler D, Reid G, Enklaar T, Wolff NA, Ebbinghaus C, Hillemann A, Schulten HJ, Gunawan B, Fuzesi L, Zabel B, Burckhardt G: Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. Biochem Biophys Res Commun. 2000 Aug 28;275(2):623-30. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Groves CE, Munoz L, Bahn A, Burckhardt G, Wright SH: Interaction of cysteine conjugates with human and rabbit organic anion transporter 1. J Pharmacol Exp Ther. 2003 Feb;304(2):560-6. [Article]
- Tanaka K, Xu W, Zhou F, You G: Role of glycosylation in the organic anion transporter OAT1. J Biol Chem. 2004 Apr 9;279(15):14961-6. Epub 2004 Jan 28. [Article]
- Hong M, Zhou F, You G: Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. J Biol Chem. 2004 Jul 23;279(30):31478-82. Epub 2004 May 15. [Article]
- Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB: Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005 May;313(2):621-8. Epub 2005 Jan 11. [Article]
- Tahara H, Shono M, Kusuhara H, Kinoshita H, Fuse E, Takadate A, Otagiri M, Sugiyama Y: Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. Pharm Res. 2005 Apr;22(4):647-60. Epub 2005 Apr 7. [Article]
- Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB: A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem. 2006 Dec 8;281(49):38071-9. Epub 2006 Oct 11. [Article]
- Mizuno N, Takahashi T, Iwase Y, Kusuhara H, Niwa T, Sugiyama Y: Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34. Epub 2007 May 14. [Article]
- Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB: Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther. 2005 Aug;314(2):923-31. Epub 2005 May 24. [Article]
- Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK: Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct;68(4):1491-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Furosemide approved, vet_approved unknown transporter inhibitorinducer Details Salicylic acid approved, investigational, vet_approved unknown transporter inhibitor Details Probenecid approved, investigational unknown transporter substrateinhibitor Details Aminohippuric acid approved, investigational unknown transporter substrateinhibitor Details Ketoprofen approved, vet_approved unknown transporter inhibitor Details Glutaric Acid experimental unknown transporter substrateinhibitor Details Cidofovir approved unknown transporter substrateinhibitor Details Cefradine approved unknown transporter inhibitor Details Adefovir dipivoxil approved, investigational unknown transporter substrateinhibitor Details Piroxicam approved, investigational unknown transporter inhibitor Details Phenacetin withdrawn unknown transporter inhibitor Details Naproxen approved, vet_approved unknown transporter inhibitor Details Indomethacin approved, investigational unknown transporter substrateinhibitor Details Ibuprofen approved unknown transporter inhibitor Details Flurbiprofen approved, investigational unknown transporter inhibitor Details Etodolac approved, investigational, vet_approved unknown transporter inhibitor Details Diflunisal approved, investigational unknown transporter inhibitor Details Diclofenac approved, vet_approved unknown transporter inhibitor Details Cilastatin approved, investigational unknown transporter inhibitor Details Benzylpenicillin approved, vet_approved unknown transporter inhibitor Details Caprylic acid investigational unknown transporter inhibitor Details Cimetidine approved, investigational unknown transporter substrateinhibitor Details Aspartame investigational, nutraceutical unknown transporter inhibitor Details Tetracycline approved, vet_approved, withdrawn unknown transporter inhibitor Details Oxytetracycline approved, investigational, vet_approved unknown transporter substrateinhibitor Details Minocycline approved, investigational unknown transporter inhibitor Details Doxycycline approved, investigational, vet_approved unknown transporter inhibitor Details Ganciclovir approved, investigational unknown transporter inhibitor Details Acyclovir approved unknown transporter substrateinhibitor Details Dinoprostone approved unknown transporter substrateinhibitor Details Cefalotin approved, investigational, vet_approved unknown transporter inhibitor Details Ceftriaxone approved unknown transporter inhibitor Details Cefotaxime approved unknown transporter inhibitor Details Cefoperazone approved, investigational unknown transporter inhibitor Details Cefazolin approved unknown transporter substrateinhibitor Details Cefamandole approved, experimental unknown transporter inhibitor Details Cefadroxil approved, vet_approved, withdrawn unknown transporter inhibitor Details Phenylbutazone approved, vet_approved unknown transporter inhibitor Details Methotrexate approved unknown transporter substrateinhibitor Details Fluorescein approved unknown transporter substrateinhibitor Details Losartan approved unknown transporter inhibitor Details Hydrochlorothiazide approved, vet_approved unknown transporter substrateinhibitor Details Bumetanide approved unknown transporter substrateinhibitor Details Pravastatin approved no transporter inhibitor Details Caspofungin approved unknown transporter inhibitor Details Sulindac approved, investigational unknown transporter inhibitor Details Riboflavin approved, investigational, nutraceutical, vet_approved unknown transporter inhibitor Details Folic acid approved, nutraceutical, vet_approved unknown transporter inhibitor Details Enalapril approved, vet_approved unknown transporter inhibitor Details Carprofen approved, vet_approved, withdrawn unknown transporter inhibitor Details Captopril approved unknown transporter substrateinhibitor Details Tolbutamide approved, investigational unknown transporter inhibitor Details Amoxicillin approved, vet_approved unknown transporter inhibitor Details Cephalexin approved, investigational, vet_approved unknown transporter substrateinhibitor Details Valproic acid approved, investigational unknown transporter inhibitor Details Nalidixic acid approved, investigational unknown transporter inhibitor Details Etacrynic acid approved, investigational unknown transporter inhibitor Details Cyclosporine approved, investigational, vet_approved unknown transporter substrateinhibitor Details Methazolamide approved unknown transporter inhibitor Details Ethoxzolamide withdrawn unknown transporter inhibitor Details Cyclothiazide approved unknown transporter inhibitor Details Chlorothiazide approved, vet_approved unknown transporter inhibitor Details Acetazolamide approved, vet_approved unknown transporter inhibitor Details Flufenamic acid approved unknown transporter inhibitor Details Tolmetin approved unknown transporter inhibitor Details Acetylsalicylic acid approved, vet_approved unknown transporter inhibitor Details Antipyrine approved, investigational unknown transporter inhibitor Details Oxyphenbutazone approved, withdrawn unknown transporter inhibitor Details Meclofenamic acid approved, vet_approved unknown transporter inhibitor Details Aminophenazone approved, withdrawn unknown transporter inhibitor Details Nateglinide approved, investigational unknown transporter inhibitor Details Piperacillin approved unknown transporter inhibitor Details Ofloxacin approved unknown transporter inhibitor Details Norfloxacin approved unknown transporter inhibitor Details Nafcillin approved, investigational unknown transporter inhibitor Details Cinoxacin approved, investigational, withdrawn unknown transporter inhibitor Details Chloramphenicol approved, vet_approved, withdrawn unknown transporter inhibitor Details Ceftazidime approved unknown transporter inhibitor Details Carbenicillin approved, investigational unknown transporter inhibitor Details Trifluridine approved, investigational unknown transporter substrateinhibitor Details Glyburide approved unknown transporter inhibitor Details Taurocholic acid approved, experimental unknown transporter substrateinhibitor Details Foscarnet approved unknown transporter inhibitor Details Chlorpropamide approved, investigational unknown transporter inhibitor Details Cefotiam approved, investigational unknown transporter substrateinhibitor Details Novobiocin approved, investigational, vet_approved, withdrawn unknown transporter inhibitor Details Conjugated estrogens approved unknown transporter substrate Details Cyclic adenosine monophosphate experimental unknown transporter substrate Details Lamivudine approved, investigational unknown transporter substrate Details Grepafloxacin approved, investigational, withdrawn unknown transporter substrate Details Stavudine approved, investigational unknown transporter substrate Details Zalcitabine approved, investigational unknown transporter substrate Details Didanosine approved unknown transporter substrate Details Probenecid approved, investigational yes target inhibitor Details Bromodiphenhydramine approved unknown transporter Details Cefacetrile experimental, vet_approved unknown transporter substrateinhibitor Details Latanoprost approved, investigational unknown transporter substrateinhibitor Details Valaciclovir approved, investigational unknown transporter Details GS 0573 investigational unknown transporter Details Zidovudine approved unknown transporter substrate Details Cyclic GMP experimental unknown transporter Details Uric acid investigational unknown transporter Details Dinoprost tromethamine approved, vet_approved unknown transporter Details Acetylcysteine approved, investigational unknown transporter substrate Details Ellagic acid investigational unknown transporter substrateinhibitor Details Degraded Cephaloridine experimental unknown transporter Details Acamprosate approved, investigational unknown transporter substrate Details Dabrafenib approved, investigational no transporter inhibitor Details Tenofovir disoproxil approved, investigational unknown transporter substrate Details Cefotaxime approved unknown target Details Ceftriaxone approved unknown target Details Topiroxostat experimental unknown transporter inhibitor Details Ataluren approved, investigational no enzyme inhibitor Details Enasidenib approved, investigational unknown transporter inhibitor Details Dolutegravir approved no transporter inhibitor Details Rucaparib approved, investigational no transporter inhibitor Details Baricitinib approved, investigational unknown transporter inhibitor Details Cefdinir approved unknown transporter substrate Details Ceftibuten approved, investigational unknown transporter substrate Details Ceftizoxime approved, withdrawn unknown transporter substrateinhibitor Details Cefaloridine experimental, withdrawn unknown transporter substrate Details Citrulline investigational, nutraceutical unknown transporter substrate Details Edaravone approved, investigational no transporter substrate Details Alprostadil approved, investigational unknown transporter substrateinhibitor Details Silibinin experimental, investigational unknown transporter substrateinhibitor Details Lenvatinib approved, investigational unknown transporter inhibitor Details Tazobactam approved unknown transporter substrateinhibitor Details Rifampin approved unknown transporter inhibitor Details Cabotegravir approved, investigational unknown transporter inhibitor Details Dexibuprofen approved, investigational unknown transporter Details Tenofovir alafenamide approved no transporter substrate Details Tenofovir experimental, investigational no transporter substrate Details Istradefylline approved, investigational unknown transporter inhibitor Details Ubrogepant approved, investigational unknown transporter substrate Details Famotidine approved no transporter substrate Details Tafamidis approved, investigational unknown transporter inhibitor Details Favipiravir approved, investigational unknown transporter inhibitor Details Osilodrostat approved, investigational unknown transporter inhibitor Details Hydroflumethiazide approved, investigational, withdrawn unknown transporter substrateinhibitor Details Polythiazide approved unknown transporter substrate Details Pralsetinib approved, investigational no transporter inhibitor Details Fosdenopterin approved unknown transporter inhibitor Details Linezolid approved, investigational no transporter inhibitor Details Brincidofovir approved, investigational no transporter inhibitor Details Fexinidazole approved, investigational unknown transporter inhibitor Details Atogepant approved, investigational no transporter substrate Details Romidepsin approved, investigational no transporter inhibitor Details Pafolacianine approved, investigational no transporter substrate Details Roxadustat approved, investigational unknown transporter substrate Details Linzagolix approved no transporter inhibitor Details Pemetrexed approved, investigational no transporter substrate Details Daprodustat approved, investigational no transporter substrate Details Olsalazine approved unknown transporter upregulator Details Omaveloxolone approved, investigational unknown transporter inhibitor Details Tezacaftor approved, investigational no transporter inhibitor Details Vadadustat approved, investigational unknown transporter substrate Details Durlobactam approved, investigational no transporter substrate Details Encorafenib approved, investigational no transporter inhibitor Details Sulbactam approved unknown transporter substrate Details L-Acetylleucine approved, investigational no transporter substrateinhibitor Details