Solute carrier family 22 member 6

BE0001066ProteinHumansSLC22A6

Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such... It is acted on by 177 drugs in DrugBank.

Gene name
SLC22A6
UniProtKB entry
Q4U2R8Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
563 residues · 61,816 Da
Also known as
hOAT1 · hPAHT · hROAT1 · OAT1 · Organic anion transporter 1

Resolves to

Protein
UniProtQ4U2R8UniProt nameS22A6_HUMAN
Gene
HGNCHGNC:10970NCBI Gene9356GenBank3831566GeneCardsSLC22A6
Pharmacology
IUPHAR/GtoPdb1025KEGGhsa:9356
Structure
PDB9J02PDB9J04PDB9J06
Drugs

What you can answer from here — as of September 07, 2019

177DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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372+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 22 member 6, how selective are they, and which programs against it are still in active trials?

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