Solute carrier family 22 member 6

Details

Name
Solute carrier family 22 member 6
Kind
protein
Synonyms
  • hOAT1
  • hPAHT
  • hROAT1
  • OAT1
  • Organic anion transporter 1
  • PAH transporter
  • PAHT
  • Renal organic anion transporter 1
Gene Name
SLC22A6
UniProtKB Entry
Q4U2R8Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037120|Solute carrier family 22 member 6
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
RQQQEHQKYMVPLQASAQEKNGL
Number of residues
563
Molecular Weight
61815.78
Theoretical pI
8.78
GO Classification
Functions
alpha-ketoglutarate transmembrane transporter activity / antiporter activity / identical protein binding / prostaglandin transmembrane transporter activity / solute / transmembrane transporter activity / xenobiotic transmembrane transporter activity
Processes
metanephric proximal tubule development / monoatomic anion transport / prostaglandin transport / response to organic cyclic compound
Components
basal plasma membrane / protein-containing complex
General Function
Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:11669456, PubMed:11907186, PubMed:14675047, PubMed:22108572, PubMed:23832370, PubMed:28534121, PubMed:9950961). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (PubMed:9887087). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:11907186). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:26377792). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:22108572, PubMed:23832370). May transport glutamate (PubMed:26377792). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:11669456, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate (PubMed:14675047, PubMed:26377792). Xenobiotics include the mycotoxin ochratoxin (OTA) (PubMed:11669456). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (PubMed:35307651)
Specific Function
alpha-ketoglutarate transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
10-30 136-156 165-187 191-213 225-245 249-269 338-358 369-389 396-416 426-446 456-475 485-505
Cellular Location
Basolateral cell membrane
Gene sequence
>lcl|BSEQ0010747|Solute carrier family 22 member 6 (SLC22A6)
ATGGCCTTTAATGACCTCCTGCAGCAGGTGGGGGGTGTCGGCCGCTTCCAGCAGATCCAG
GTCACCCTGGTGGTCCTCCCCCTGCTCCTGATGGCTTCTCACAACACCCTGCAGAACTTC
ACTGCTGCCATCCCTACCCACCACTGCCGCCCGCCTGCCGATGCCAACCTCAGCAAGAAC
GGGGGGCTGGAGGTCTGGCTGCCCCGGGACAGGCAGGGGCAGCCTGAGTCCTGCCTCCGC
TTCACCTCCCCGCAGTGGGGACTGCCCTTTCTCAATGGCACAGAAGCCAATGGCACAGGG
GCCACAGAGCCCTGCACCGATGGCTGGATCTATGACAACAGCACCTTCCCATCTACCATC
GTGACTGAGTGGGACCTTGTGTGCTCTCACAGGGCCCTACGCCAGCTGGCCCAGTCCTTG
TACATGGTGGGGGTGCTGCTCGGAGCCATGGTGTTCGGCTACCTTGCAGACAGGCTAGGC
CGCCGGAAGGTACTCATCTTGAACTACCTGCAGACAGCTGTGTCAGGGACCTGCGCAGCC
TTCGCACCCAACTTCCCCATCTACTGCGCCTTCCGGCTCCTCTCGGGCATGGCTCTGGCT
GGCATCTCCCTCAACTGCATGACACTGAATGTGGAGTGGATGCCCATTCACACACGGGCC
TGCGTGGGCACCTTGATTGGCTATGTCTACAGCCTGGGCCAGTTCCTCCTGGCTGGTGTG
GCCTACGCTGTGCCCCACTGGCGCCACCTGCAGCTACTGGTCTCTGCGCCTTTTTTTGCC
TTCTTCATCTACTCCTGGTTCTTCATTGAGTCGGCCCGCTGGCACTCCTCCTCCGGGAGG
CTGGACCTCACCCTGAGGGCCCTGCAGAGAGTCGCCCGGATCAATGGGAAGCGGGAAGAA
GGAGCCAAATTGAGTATGGAGGTACTCCGGGCCAGTCTGCAGAAGGAGCTGACCATGGGC
AAAGGCCAGGCATCGGCCATGGAGCTGCTGCGCTGCCCCACCCTCCGCCACCTCTTCCTC
TGCCTCTCCATGCTGTGGTTTGCCACTAGCTTTGCATACTATGGGCTGGTCATGGACCTG
CAGGGCTTTGGAGTCAGCATCTACCTAATCCAGGTGATCTTTGGTGCTGTGGACCTGCCT
GCCAAGCTTGTGGGCTTCCTTGTCATCAACTCCCTGGGTCGCCGGCCTGCCCAGATGGCT
GCACTGCTGCTGGCAGGCATCTGCATCCTGCTCAATGGGGTGATACCCCAGGACCAGTCC
ATTGTCCGAACCTCTCTTGCTGTGCTGGGGAAGGGTTGTCTGGCTGCCTCCTTCAACTGC
ATCTTCCTGTATACTGGGGAACTGTATCCCACAATGATCCGGCAGACAGGCATGGGAATG
GGCAGCACCATGGCCCGAGTGGGCAGCATCGTGAGCCCACTGGTGAGCATGACTGCCGAG
CTCTACCCCTCCATGCCTCTCTTCATCTACGGTGCTGTTCCTGTGGCCGCCAGCGCTGTC
ACTGTCCTCCTGCCAGAGACCCTGGGCCAGCCACTGCCAGACACGGTGCAGGACCTGGAG
AGCAGGTGGGCCCCCACTCAGAAAGAAGCAGGGATATATCCCAGGAAAGGGAAACAGACG
CGACAGCAACAAGAGCACCAGAAGTATATGGTCCCACTGCAGGCCTCAGCACAAGAGAAG
AATGGACTCTGA
Chromosome Location
11
Locus
11q12.3
External Identifiers
ResourceLink
UniProtKB IDQ4U2R8
UniProtKB Entry NameS22A6_HUMAN
GenBank Protein ID3831566
GenBank Gene IDAF057039
GeneCard IDSLC22A6
GenAtlas IDhROAT1
HGNC IDHGNC:10970
KEGG IDhsa:9356
IUPHAR/Guide To Pharmacology ID1025
NCBI Gene ID9356
General References
  1. Reid G, Wolff NA, Dautzenberg FM, Burckhardt G: Cloning of a human renal p-aminohippurate transporter, hROAT1. Kidney Blood Press Res. 1998;21(2-4):233-7. [Article]
  2. Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 Jan;276(1 Pt 2):F122-8. [Article]
  3. Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. [Article]
  4. Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [Article]
  5. Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999 Sep;56(3):570-80. [Article]
  6. Bahn A, Prawitt D, Buttler D, Reid G, Enklaar T, Wolff NA, Ebbinghaus C, Hillemann A, Schulten HJ, Gunawan B, Fuzesi L, Zabel B, Burckhardt G: Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. Biochem Biophys Res Commun. 2000 Aug 28;275(2):623-30. [Article]
  7. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
  8. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  9. Groves CE, Munoz L, Bahn A, Burckhardt G, Wright SH: Interaction of cysteine conjugates with human and rabbit organic anion transporter 1. J Pharmacol Exp Ther. 2003 Feb;304(2):560-6. [Article]
  10. Tanaka K, Xu W, Zhou F, You G: Role of glycosylation in the organic anion transporter OAT1. J Biol Chem. 2004 Apr 9;279(15):14961-6. Epub 2004 Jan 28. [Article]
  11. Hong M, Zhou F, You G: Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. J Biol Chem. 2004 Jul 23;279(30):31478-82. Epub 2004 May 15. [Article]
  12. Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB: Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005 May;313(2):621-8. Epub 2005 Jan 11. [Article]
  13. Tahara H, Shono M, Kusuhara H, Kinoshita H, Fuse E, Takadate A, Otagiri M, Sugiyama Y: Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. Pharm Res. 2005 Apr;22(4):647-60. Epub 2005 Apr 7. [Article]
  14. Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB: A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem. 2006 Dec 8;281(49):38071-9. Epub 2006 Oct 11. [Article]
  15. Mizuno N, Takahashi T, Iwase Y, Kusuhara H, Niwa T, Sugiyama Y: Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34. Epub 2007 May 14. [Article]
  16. Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB: Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther. 2005 Aug;314(2):923-31. Epub 2005 May 24. [Article]
  17. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK: Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct;68(4):1491-9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Furosemideapproved, vet_approvedunknowntransporterinhibitorinducerDetails
Salicylic acidapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Probenecidapproved, investigationalunknowntransportersubstrateinhibitorDetails
Aminohippuric acidapproved, investigationalunknowntransportersubstrateinhibitorDetails
Ketoprofenapproved, vet_approvedunknowntransporterinhibitorDetails
Glutaric AcidexperimentalunknowntransportersubstrateinhibitorDetails
CidofovirapprovedunknowntransportersubstrateinhibitorDetails
CefradineapprovedunknowntransporterinhibitorDetails
Adefovir dipivoxilapproved, investigationalunknowntransportersubstrateinhibitorDetails
Piroxicamapproved, investigationalunknowntransporterinhibitorDetails
PhenacetinwithdrawnunknowntransporterinhibitorDetails
Naproxenapproved, vet_approvedunknowntransporterinhibitorDetails
Indomethacinapproved, investigationalunknowntransportersubstrateinhibitorDetails
IbuprofenapprovedunknowntransporterinhibitorDetails
Flurbiprofenapproved, investigationalunknowntransporterinhibitorDetails
Etodolacapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Diflunisalapproved, investigationalunknowntransporterinhibitorDetails
Diclofenacapproved, vet_approvedunknowntransporterinhibitorDetails
Cilastatinapproved, investigationalunknowntransporterinhibitorDetails
Benzylpenicillinapproved, vet_approvedunknowntransporterinhibitorDetails
Caprylic acidinvestigationalunknowntransporterinhibitorDetails
Cimetidineapproved, investigationalunknowntransportersubstrateinhibitorDetails
Aspartameinvestigational, nutraceuticalunknowntransporterinhibitorDetails
Tetracyclineapproved, vet_approved, withdrawnunknowntransporterinhibitorDetails
Oxytetracyclineapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Minocyclineapproved, investigationalunknowntransporterinhibitorDetails
Doxycyclineapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Ganciclovirapproved, investigationalunknowntransporterinhibitorDetails
AcyclovirapprovedunknowntransportersubstrateinhibitorDetails
DinoprostoneapprovedunknowntransportersubstrateinhibitorDetails
Cefalotinapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
CeftriaxoneapprovedunknowntransporterinhibitorDetails
CefotaximeapprovedunknowntransporterinhibitorDetails
Cefoperazoneapproved, investigationalunknowntransporterinhibitorDetails
CefazolinapprovedunknowntransportersubstrateinhibitorDetails
Cefamandoleapproved, experimentalunknowntransporterinhibitorDetails
Cefadroxilapproved, vet_approved, withdrawnunknowntransporterinhibitorDetails
Phenylbutazoneapproved, vet_approvedunknowntransporterinhibitorDetails
MethotrexateapprovedunknowntransportersubstrateinhibitorDetails
FluoresceinapprovedunknowntransportersubstrateinhibitorDetails
LosartanapprovedunknowntransporterinhibitorDetails
Hydrochlorothiazideapproved, vet_approvedunknowntransportersubstrateinhibitorDetails
BumetanideapprovedunknowntransportersubstrateinhibitorDetails
PravastatinapprovednotransporterinhibitorDetails
CaspofunginapprovedunknowntransporterinhibitorDetails
Sulindacapproved, investigationalunknowntransporterinhibitorDetails
Riboflavinapproved, investigational, nutraceutical, vet_approvedunknowntransporterinhibitorDetails
Folic acidapproved, nutraceutical, vet_approvedunknowntransporterinhibitorDetails
Enalaprilapproved, vet_approvedunknowntransporterinhibitorDetails
Carprofenapproved, vet_approved, withdrawnunknowntransporterinhibitorDetails
CaptoprilapprovedunknowntransportersubstrateinhibitorDetails
Tolbutamideapproved, investigationalunknowntransporterinhibitorDetails
Amoxicillinapproved, vet_approvedunknowntransporterinhibitorDetails
Cephalexinapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Valproic acidapproved, investigationalunknowntransporterinhibitorDetails
Nalidixic acidapproved, investigationalunknowntransporterinhibitorDetails
Etacrynic acidapproved, investigationalunknowntransporterinhibitorDetails
Cyclosporineapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
MethazolamideapprovedunknowntransporterinhibitorDetails
EthoxzolamidewithdrawnunknowntransporterinhibitorDetails
CyclothiazideapprovedunknowntransporterinhibitorDetails
Chlorothiazideapproved, vet_approvedunknowntransporterinhibitorDetails
Acetazolamideapproved, vet_approvedunknowntransporterinhibitorDetails
Flufenamic acidapprovedunknowntransporterinhibitorDetails
TolmetinapprovedunknowntransporterinhibitorDetails
Acetylsalicylic acidapproved, vet_approvedunknowntransporterinhibitorDetails
Antipyrineapproved, investigationalunknowntransporterinhibitorDetails
Oxyphenbutazoneapproved, withdrawnunknowntransporterinhibitorDetails
Meclofenamic acidapproved, vet_approvedunknowntransporterinhibitorDetails
Aminophenazoneapproved, withdrawnunknowntransporterinhibitorDetails
Nateglinideapproved, investigationalunknowntransporterinhibitorDetails
PiperacillinapprovedunknowntransporterinhibitorDetails
OfloxacinapprovedunknowntransporterinhibitorDetails
NorfloxacinapprovedunknowntransporterinhibitorDetails
Nafcillinapproved, investigationalunknowntransporterinhibitorDetails
Cinoxacinapproved, investigational, withdrawnunknowntransporterinhibitorDetails
Chloramphenicolapproved, vet_approved, withdrawnunknowntransporterinhibitorDetails
CeftazidimeapprovedunknowntransporterinhibitorDetails
Carbenicillinapproved, investigationalunknowntransporterinhibitorDetails
Trifluridineapproved, investigationalunknowntransportersubstrateinhibitorDetails
GlyburideapprovedunknowntransporterinhibitorDetails
Taurocholic acidapproved, experimentalunknowntransportersubstrateinhibitorDetails
FoscarnetapprovedunknowntransporterinhibitorDetails
Chlorpropamideapproved, investigationalunknowntransporterinhibitorDetails
Cefotiamapproved, investigationalunknowntransportersubstrateinhibitorDetails
Novobiocinapproved, investigational, vet_approved, withdrawnunknowntransporterinhibitorDetails
Conjugated estrogensapprovedunknowntransportersubstrateDetails
Cyclic adenosine monophosphateexperimentalunknowntransportersubstrateDetails
Lamivudineapproved, investigationalunknowntransportersubstrateDetails
Grepafloxacinapproved, investigational, withdrawnunknowntransportersubstrateDetails
Stavudineapproved, investigationalunknowntransportersubstrateDetails
Zalcitabineapproved, investigationalunknowntransportersubstrateDetails
DidanosineapprovedunknowntransportersubstrateDetails
Probenecidapproved, investigationalyestargetinhibitorDetails
BromodiphenhydramineapprovedunknowntransporterDetails
Cefacetrileexperimental, vet_approvedunknowntransportersubstrateinhibitorDetails
Latanoprostapproved, investigationalunknowntransportersubstrateinhibitorDetails
Valaciclovirapproved, investigationalunknowntransporterDetails
GS 0573investigationalunknowntransporterDetails
ZidovudineapprovedunknowntransportersubstrateDetails
Cyclic GMPexperimentalunknowntransporterDetails
Uric acidinvestigationalunknowntransporterDetails
Dinoprost tromethamineapproved, vet_approvedunknowntransporterDetails
Acetylcysteineapproved, investigationalunknowntransportersubstrateDetails
Ellagic acidinvestigationalunknowntransportersubstrateinhibitorDetails
Degraded CephaloridineexperimentalunknowntransporterDetails
Acamprosateapproved, investigationalunknowntransportersubstrateDetails
Dabrafenibapproved, investigationalnotransporterinhibitorDetails
Tenofovir disoproxilapproved, investigationalunknowntransportersubstrateDetails
CefotaximeapprovedunknowntargetDetails
CeftriaxoneapprovedunknowntargetDetails
TopiroxostatexperimentalunknowntransporterinhibitorDetails
Atalurenapproved, investigationalnoenzymeinhibitorDetails
Enasidenibapproved, investigationalunknowntransporterinhibitorDetails
DolutegravirapprovednotransporterinhibitorDetails
Rucaparibapproved, investigationalnotransporterinhibitorDetails
Baricitinibapproved, investigationalunknowntransporterinhibitorDetails
CefdinirapprovedunknowntransportersubstrateDetails
Ceftibutenapproved, investigationalunknowntransportersubstrateDetails
Ceftizoximeapproved, withdrawnunknowntransportersubstrateinhibitorDetails
Cefaloridineexperimental, withdrawnunknowntransportersubstrateDetails
Citrullineinvestigational, nutraceuticalunknowntransportersubstrateDetails
Edaravoneapproved, investigationalnotransportersubstrateDetails
Alprostadilapproved, investigationalunknowntransportersubstrateinhibitorDetails
Silibininexperimental, investigationalunknowntransportersubstrateinhibitorDetails
Lenvatinibapproved, investigationalunknowntransporterinhibitorDetails
TazobactamapprovedunknowntransportersubstrateinhibitorDetails
RifampinapprovedunknowntransporterinhibitorDetails
Cabotegravirapproved, investigationalunknowntransporterinhibitorDetails
Dexibuprofenapproved, investigationalunknowntransporterDetails
Tenofovir alafenamideapprovednotransportersubstrateDetails
Tenofovirexperimental, investigationalnotransportersubstrateDetails
Istradefyllineapproved, investigationalunknowntransporterinhibitorDetails
Ubrogepantapproved, investigationalunknowntransportersubstrateDetails
FamotidineapprovednotransportersubstrateDetails
Tafamidisapproved, investigationalunknowntransporterinhibitorDetails
Favipiravirapproved, investigationalunknowntransporterinhibitorDetails
Osilodrostatapproved, investigationalunknowntransporterinhibitorDetails
Hydroflumethiazideapproved, investigational, withdrawnunknowntransportersubstrateinhibitorDetails
PolythiazideapprovedunknowntransportersubstrateDetails
Pralsetinibapproved, investigationalnotransporterinhibitorDetails
FosdenopterinapprovedunknowntransporterinhibitorDetails
Linezolidapproved, investigationalnotransporterinhibitorDetails
Brincidofovirapproved, investigationalnotransporterinhibitorDetails
Fexinidazoleapproved, investigationalunknowntransporterinhibitorDetails
Atogepantapproved, investigationalnotransportersubstrateDetails
Romidepsinapproved, investigationalnotransporterinhibitorDetails
Pafolacianineapproved, investigationalnotransportersubstrateDetails
Roxadustatapproved, investigationalunknowntransportersubstrateDetails
LinzagolixapprovednotransporterinhibitorDetails
Pemetrexedapproved, investigationalnotransportersubstrateDetails
Daprodustatapproved, investigationalnotransportersubstrateDetails
OlsalazineapprovedunknowntransporterupregulatorDetails
Omaveloxoloneapproved, investigationalunknowntransporterinhibitorDetails
Tezacaftorapproved, investigationalnotransporterinhibitorDetails
Vadadustatapproved, investigationalunknowntransportersubstrateDetails
Durlobactamapproved, investigationalnotransportersubstrateDetails
Encorafenibapproved, investigationalnotransporterinhibitorDetails
SulbactamapprovedunknowntransportersubstrateDetails
L-Acetylleucineapproved, investigationalnotransportersubstrateinhibitorDetails