Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

Article Details

Citation

Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA

Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

Genome Res. 1997 Mar;7(3):268-80.

PubMed ID
9074930 [ View in PubMed
]
Abstract

The detailed genomic organization of a gene-dense region at human chromosome 12p13, spanning 223 kb of contiguous sequence, was determined. This region is composed of 20 genes and several other expressed sequences. Experimental tools including RT-PCR and cDNA sequencing, combined with gene prediction programs, were utilized in the analysis of the sequence. Various computer software programs were employed for sequence similarity searches and functional predictions. The high number of genes with diverse functions and complex transcriptional patterns make this region ideal for addressing challenges of gene discovery and genomic characterization amenable to large-scale sequence analysis.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Prolyl 3-hydroxylase 3Q8IVL6Details
T-cell surface glycoprotein CD4P01730Details
Triosephosphate isomeraseP60174Details
Gamma-enolaseP09104Details
Prohibitin-2Q99623Details
Tyrosine-protein phosphatase non-receptor type 6P29350Details