HBV genotypic variability in Cuba.
Article Details
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Loureiro CL, Aguilar JC, Aguiar J, Muzio V, Penton E, Garcia D, Guillen G, Pujol FH
HBV genotypic variability in Cuba.
PLoS One. 2015 Mar 5;10(3):e0118959. doi: 10.1371/journal.pone.0118959. eCollection 2015.
- PubMed ID
- 25742179 [ View in PubMed]
- Abstract
The genetic diversity of HBV in human population is often a reflection of its genetic admixture. The aim of this study was to explore the genotypic diversity of HBV in Cuba. The S genomic region of Cuban HBV isolates was sequenced and for selected isolates the complete genome or precore-core sequence was analyzed. The most frequent genotype was A (167/250, 67%), mainly A2 (149, 60%) but also A1 and one A4. A total of 77 isolates were classified as genotype D (31%), with co-circulation of several subgenotypes (56 D4, 2 D1, 5 D2, 7 D3/6 and 7 D7). Three isolates belonged to genotype E, two to H and one to B3. Complete genome sequence analysis of selected isolates confirmed the phylogenetic analysis performed with the S region. Mutations or polymorphisms in precore region were more common among genotype D compared to genotype A isolates. The HBV genotypic distribution in this Caribbean island correlates with the Y lineage genetic background of the population, where a European and African origin prevails. HBV genotypes E, B3 and H isolates might represent more recent introductions.