Plasma dopamine and noradrenaline variations in response to stress.

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LeBlanc J, Ducharme MB

Plasma dopamine and noradrenaline variations in response to stress.

Physiol Behav. 2007 Jun 8;91(2-3):208-11. Epub 2007 Mar 2.

PubMed ID

17433386 [ View in PubMed

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Abstract

Dopamine (DA) the precursor of noradrenaline (NA) has been shown to have many functions such as its influence on endorphins activity and its association with hedonic impact, anxiety and depression. However with regard to the sympathetic nervous system activity, the role of DA has merely been considered as being the precursor of NA. We have shown in a previous study a positive correlation between the resting plasma level of NA and those found during exposure to a physical stress. No explanation was proposed to explain this finding. Enhanced sympathetic nervous system activity has been shown to increase the secretion of NA as well as DA. It is not known however if the secretion of DA during exposure to stress parallels that of NA. What are the interactions between the two amines and also between values at rest and during exposure to stress? For that reason a test was used which consisted of blowing cold wind (4 degrees C at 60 km/h) on the face of a group of subjects and measuring plasma concentration of the two amines before, during and after the test. For a given individual, the increase of either plasma NA or DA in response to the cold wind stress parallels the resting plasma concentrations of these two amines respectively. Low level of one amine at rest coincides with low increase during the stress. Furthermore the results have shown that when the plasma level of either one of these two amines is high in response to stress, the values of the other amine are small; both amines are not high or low at the same time. The literature suggests that dopamine beta hydroxylase (DBH), the enzyme which catalyzes the synthesis of NA from DA, may provide an explanation to our findings. Lower DBH activity of this enzyme would result in a lower NA and a greater DA storage and secretion. Further investigation is needed to verify this possibility.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dopamine	Dopamine beta-hydroxylase	Protein	Humans	Yes	Ligand	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Dopamine	Dopamine beta-hydroxylase	Protein	Humans	Unknown	Substrate	Details