New members of the chemokine receptor gene family.

Article Details


Raport CJ, Schweickart VL, Chantry D, Eddy RL Jr, Shows TB, Godiska R, Gray PW

New members of the chemokine receptor gene family.

J Leukoc Biol. 1996 Jan;59(1):18-23.

PubMed ID
8558062 [ View in PubMed

Chemokines are relatively small peptides with potent chemoattractant and activation activities for leukocytes. Several chemokine receptors have been cloned and characterized and all are members of the G protein-coupled receptor superfamily. Using degenerate oligonucleotides and polymerase chain reaction, we have identified seven novel receptors. Two of these sequences are presented here for the first time. We have shown, with gene mapping studies, that receptors with the highest sequence similarity are closely linked on human chromosomes. This close genetic association suggests a functional relationship as well.

DrugBank Data that Cites this Article

NameUniProt ID
Leukotriene B4 receptor 1Q15722Details
Uracil nucleotide/cysteinyl leukotriene receptorQ13304Details