Blockade of tetanic- and calcium-induced long-term potentiation in the hippocampal slice preparation by neuroleptics.
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Mody I, Baimbridge KG, Miller JJ
Blockade of tetanic- and calcium-induced long-term potentiation in the hippocampal slice preparation by neuroleptics.
Neuropharmacology. 1984 Jun;23(6):625-31.
- PubMed ID
- 6146939 [ View in PubMed]
- Abstract
The effect of neuroleptics which block calmodulin was studied on two forms of long-term potentiation of field responses evoked by stratum radiatum stimulation of the CA1 region in the in vitro preparation of hippocampal slices. Tetanic stimulation or brief exposure to 4 mM Ca2+ produced a long-lasting augmentation of the extracellular excitatory postsynaptic potentials EPSP) and of the responses of the population spikes. Both forms of potentiation were inhibited by perfusion of 10 microM trifluoperazine (TFP) or pimozide, an effect which is unlikely to involve interactions with dopamine or norepinephrine receptors, but rather a potent blockade of calmodulin-mediated events. The results suggest that induction of the "permanency" of both tetanic- and calcium-induced long term potentiation requires activation of calmodulin and involves some calmodulin-mediated mechanism(s).
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Pimozide Calmodulin Protein Humans UnknownInhibitorDetails