Calmodulin-1

Details

Name
Calmodulin-1
Synonyms
  • CALM
  • CAM
  • CAM1
Gene Name
CALM1
UniProtKB Entry
P0DP23Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0015487|Calmodulin-1
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Number of residues
149
Molecular Weight
16837.47
Theoretical pI
Not Available
GO Classification
Functions
adenylate cyclase activator activity / calcium channel inhibitor activity / calcium ion binding / calcium-dependent protein binding / protein kinase binding / protein phosphatase activator activity / protein serine/threonine kinase activator activity / titin binding / transmembrane transporter binding
Processes
autophagosome membrane docking / cellular response to interferon-beta / cellular response to type II interferon / detection of calcium ion / G protein-coupled receptor signaling pathway / G2/M transition of mitotic cell cycle / mitochondrion-endoplasmic reticulum membrane tethering / negative regulation of calcium ion export across plasma membrane / negative regulation of high voltage-gated calcium channel activity / negative regulation of peptidyl-threonine phosphorylation / negative regulation of ryanodine-sensitive calcium-release channel activity / organelle localization by membrane tethering / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of peptidyl-threonine phosphorylation / positive regulation of phosphoprotein phosphatase activity / positive regulation of protein autophosphorylation / positive regulation of protein dephosphorylation / positive regulation of protein serine/threonine kinase activity / positive regulation of receptor signaling pathway via JAK-STAT / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of calcium-mediated signaling / regulation of cardiac muscle cell action potential / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of cell communication by electrical coupling involved in cardiac conduction / regulation of cytokinesis / regulation of heart rate / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of ryanodine-sensitive calcium-release channel activity / response to calcium ion / substantia nigra development
Components
calcium channel complex / catalytic complex / centrosome / cytoplasm / cytosol / extracellular region / myelin sheath / nucleoplasm / nucleus / plasma membrane / protein-containing complex / sarcomere / sperm midpiece / spindle microtubule / spindle pole / vesicle / voltage-gated potassium channel complex
General Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335)
Specific Function
adenylate cyclase activator activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytoskeleton, spindle
Gene sequence
Not Available
Chromosome Location
19
Locus
19q13.32
External Identifiers
ResourceLink
UniProtKB IDP0DP23
UniProtKB Entry NameCALM1_HUMAN
GeneCard IDCALM1
HGNC IDHGNC:1442
PDB ID(s)1CDL, 1CLL, 1CTR, 1IWQ, 1J7O, 1J7P, 1K90, 1K93, 1L7Z, 1LVC, 1NKF, 1PK0, 1S26, 1SK6, 1SW8, 1UP5, 1WRZ, 1XFU, 1XFV, 1XFW, 1XFX, 1XFY, 1XFZ, 1Y6W, 1YR5, 1YRT, 1YRU, 1ZOT, 1ZUZ, 2BE6, 2F3Y, 2F3Z, 2HF5, 2I08, 2JZI, 2K0E, 2K0F, 2K0J, 2K61, 2KNE, 2KUG, 2KUH, 2L53, 2L7L, 2LGF, 2LL6, 2LL7, 2LQC, 2LQP, 2LV6, 2M0J, 2M0K, 2M55, 2MG5, 2N27, 2N6A, 2N77, 2N8J, 2R28, 2V01, 2V02, 2VAY, 2W73, 2WEL, 2X0G, 2Y4V, 3BYA, 3DVE, 3DVJ, 3DVK, 3DVM, 3EVV, 3EWT, 3EWV, 3G43, 3HR4, 3J41, 3O77, 3O78, 3OXQ, 3SUI, 3UCT, 3UCW, 3UCY, 4BW7, 4BW8, 4BYF, 4DCK, 4DJC, 4GOW, 4JPZ, 4JQ0, 4L79, 4LZX, 4M1L, 4OVN, 4Q57, 4Q5U, 4UMO, 4UPU, 4V0C, 5COC, 5DBR, 5DOW, 5DSU, 5GGM, 5I0I, 5J03, 5J8H, 5JQA, 5JTH, 5K7L, 5K8Q, 5OEO, 5TP5, 5TP6, 5V02, 5V03, 5V7X, 5WBX, 5WC5, 6B8L, 6B8M, 6B8N, 6B8P, 6B8Q, 6BUT, 6C1D, 6C1G, 6C1H, 6CNM, 6CNN, 6CNO, 6DAD, 6DAE, 6DAF, 6DAH, 6E2F, 6E2G, 6EEB, 6FEG, 6FEH, 6GDK, 6GDL, 6HCS, 6HR1, 6JI8, 6JII, 6JIU, 6JIY, 6JRS, 6JV2, 6K4K, 6K4L, 6K4R, 6M2W, 6M7H, 6MUD, 6MUE, 6N5W, 6O5G, 6OS4, 6PAW, 6PBX, 6PBY, 6TV7, 6U39, 6U3A, 6U3B, 6U3D, 6UZZ, 6V00, 6V01, 6X32, 6X33, 6X35, 6X36, 6XXX, 6XY3, 6XYR, 6Y4P, 6Y94, 6Y95, 6YA9, 6YNS, 6YNU, 6ZBI, 7AUG, 7BF1, 7BF2, 7KL5, 7L8V, 7PSZ, 7PU9, 7SHQ, 7SX3, 7SX4, 7T2Q, 7TCI, 7TCP, 7TZC, 7U9T, 7UA3, 7UA4, 7VMB, 7VUO, 7VUR, 7VUS, 7VUT, 7VUU, 7VVD, 7VVH, 7WJI, 7WR3, 7WR4, 7WR5, 7WZS, 7XN4, 7XN5, 7XN6, 7ZRP, 7ZRQ, 8AHS, 8B6Q, 8BFG, 8DGH, 8DGK, 8DUJ, 8DVE, 8EOW, 8EP0, 8EP1, 8FNY, 8FO6, 8GM4, 8GM5, 8IJK, 8J00, 8J01, 8J02, 8J03, 8J04, 8J05, 8J07, 8JFK, 8ODZ, 8OE0, 8OE4, 8PB1, 8SIK, 8SIM, 8SIN, 8UXL, 8UXM, 8W4U, 8X43, 8XYA, 8XYB
KEGG IDhsa:808
NCBI Gene ID808
General References
Not Available

Associated Data

Bio-Entities
Bio-EntityType
Calmodulin-1 (Humans)protein
primary
Calmodulin (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
tert-butanolexperimentalyestargetinhibitorDetails
TrimethyllysineexperimentalyestargetinhibitorDetails
Myristic acidexperimentalyestargetinhibitorDetails
AcetateexperimentalyestargetinhibitorDetails
Trifluoperazineapproved, investigationalyestargetinhibitorDetails
AprindineexperimentalyestargetinhibitorDetails
HalofantrineapprovedyestargetmodulatorDetails
LoperamideapprovedunknowntargetinhibitorDetails
Cinchocaineapproved, vet_approvedunknowntargetinhibitorDetails
FluphenazineapprovedunknowntargetinhibitorDetails
Isofluraneapproved, vet_approvedunknowntargetother/unknownDetails
PerphenazineapprovedunknowntargetinhibitorDetails
PhenoxybenzamineapprovedunknowntargetinhibitorDetails
Felodipineapproved, investigationalunknowntargetotherDetails
Promethazineapproved, investigationalunknowntargetinhibitorDetails
PimozideapprovedunknowntargetinhibitorDetails
CalciumnutraceuticalunknowntargetDetails
AprindineexperimentalunknowntargetinhibitorDetails
DeacetoxyvinzolidineexperimentalunknowntargetDetails
TrimethyllysineexperimentalunknowntargetDetails
tert-butanolexperimentalunknowntargetDetails
FlunarizineapprovedyestargetantagonistDetails
Bepridilapproved, withdrawnunknowntargetbinderDetails
Melatoninapproved, nutraceutical, vet_approvedunknowntargetDetails
Prenylamineapproved, withdrawnyestargetDetails
NifedipineapprovedunknowntargetinhibitorDetails
Nicardipineapproved, investigationalunknowntargetother/unknownDetails
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEexperimentalunknowntargetDetails
Myristic acidexperimentalunknowntargetDetails
N-(6-Aminohexyl)-5-Chloro-1-NaphthalenesulfonamideexperimentalunknowntargetDetails
Trifluoperazineapproved, investigationalunknowntargetinhibitorDetails
Chlorpromazineapproved, investigational, vet_approvedunknowntargetinhibitorDetails
Calcium citrateapproved, investigationalunknowntargetagonistDetails
Calcium PhosphateapprovedunknowntargetagonistDetails
Calcium levulinateapproved, experimentalunknowntargetagonistDetails
Calcium phosphate dihydrateapprovedunknowntargetDetails
Dequaliniumapproved, investigationalunknowntargetantagonistDetails