Calmodulin

Details

Name
Calmodulin
Synonyms
  • CALM
  • CALML2
  • CAM
  • CAM1
  • CAM2
  • CAM3
  • CAMB
  • CAMC
  • CAMIII
Gene Name
CALM1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037013|Calmodulin
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Number of residues
149
Molecular Weight
16837.47
Theoretical pI
3.84
GO Classification
Functions
calcium ion binding / ion channel binding / N-terminal myristoylation domain binding / nitric-oxide synthase regulator activity / phospholipase binding / protein domain specific binding / protein kinase binding / protein phosphatase activator activity / protein serine/threonine kinase activator activity / thioesterase binding / titin binding
Processes
activation of adenylate cyclase activity / activation of MAPKK activity / activation of phospholipase C activity / axon guidance / blood coagulation / carbohydrate metabolic process / detection of calcium ion / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / G-protein coupled receptor signaling pathway / glucose metabolic process / glycogen catabolic process / innate immune response / inositol phosphate metabolic process / insulin receptor signaling pathway / MAPK cascade / membrane organization / muscle contraction / negative regulation of peptidyl-threonine phosphorylation / negative regulation of ryanodine-sensitive calcium-release channel activity / neurotrophin TRK receptor signaling pathway / nitric oxide metabolic process / phototransduction, visible light / platelet activation / platelet degranulation / positive regulation of cyclic nucleotide metabolic process / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of nitric-oxide synthase activity / positive regulation of peptidyl-threonine phosphorylation / positive regulation of phosphoprotein phosphatase activity / positive regulation of protein autophosphorylation / positive regulation of protein dephosphorylation / positive regulation of protein serine/threonine kinase activity / positive regulation of ryanodine-sensitive calcium-release channel activity / Ras protein signal transduction / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of cell communication by electrical coupling involved in cardiac conduction / regulation of cytokinesis / regulation of heart rate / regulation of high voltage-gated calcium channel activity / regulation of nitric-oxide synthase activity / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of rhodopsin mediated signaling pathway / response to amphetamine / response to calcium ion / response to corticosterone / rhodopsin mediated signaling pathway / signal transduction / small GTPase mediated signal transduction / small molecule metabolic process / stimulatory C-type lectin receptor signaling pathway / substantia nigra development / synaptic transmission / vascular endothelial growth factor receptor signaling pathway
Components
centrosome / cytoplasm / cytosol / extracellular exosome / extracellular region / growth cone / nucleoplasm / nucleus / plasma membrane / sarcomere / spindle microtubule / spindle pole / vesicle
General Function
Titin binding
Specific Function
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021651|Calmodulin (CALM1)
ATGGCTGATCAGCTGACCGAAGAACAGATTGCTGAATTCAAGGAAGCCTTCTCCCTATTT
GATAAAGATGGCGATGGCACCATCACAACAAAGGAACTTGGAACTGTCATGAGGTCACTG
GGTCAGAACCCAACAGAAGCTGAATTGCAGGATATGATCAATGAAGTGGATGCTGATGGT
AATGGCACCATTGACTTCCCCGAATTTTTGACTATGATGGCTAGAAAAATGAAAGATACA
GATAGTGAAGAAGAAATCCGTGAGGCATTCCGAGTCTTTGACAAGGATGGCAATGGTTAT
ATCAGTGCAGCAGAACTACGTCACGTCATGACAAACTTAGGAGAAAAACTAACAGATGAA
GAAGTAGATGAAATGATCAGAGAAGCAGATATTGATGGAGACGGACAAGTCAACTATGAA
GAATTCGTACAGATGATGACTGCAAAATGA
Chromosome Location
19
Locus
14q24-q31
External Identifiers
ResourceLink
UniProtKB IDP0DP23
UniProtKB Entry NameCALM_HUMAN
GenBank Protein ID179888
GenBank Gene IDJ04046
GenAtlas IDCALM1
HGNC IDHGNC:1442
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00836LoperamideapprovedunknowninhibitorDetails
DB00527Cinchocaineapproved, vet_approvedunknowninhibitorDetails
DB00623FluphenazineapprovedunknowninhibitorDetails
DB00753Isofluraneapproved, vet_approvedunknownother/unknownDetails
DB00850PerphenazineapprovedunknowninhibitorDetails
DB00925PhenoxybenzamineapprovedunknowninhibitorDetails
DB01023Felodipineapproved, investigationalunknownotherDetails
DB01069Promethazineapproved, investigationalunknowninhibitorDetails
DB01100PimozideapprovedunknowninhibitorDetails
DB01373CalciumnutraceuticalunknownDetails
DB01429AprindineexperimentalunknowninhibitorDetails
DB02868DeacetoxyvinzolidineexperimentalunknownDetails
DB03977TrimethyllysineexperimentalunknownDetails
DB03900tert-butanolexperimentalunknownDetails
DB04841FlunarizineapprovedyesantagonistDetails
DB01244Bepridilapproved, withdrawnunknownbinderDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownDetails
DB04825Prenylamineapproved, withdrawnunknownDetails
DB01115NifedipineapprovedunknowninhibitorDetails
DB00622Nicardipineapproved, investigationalunknownother/unknownDetails
DB08039(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEexperimentalunknownDetails
DB08231Myristic acidexperimentalunknownDetails
DB04513N-(6-Aminohexyl)-5-Chloro-1-NaphthalenesulfonamideexperimentalunknownDetails
DB00831Trifluoperazineapproved, investigationalunknowninhibitorDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknowninhibitorDetails
DB11093Calcium citrateapproved, investigationalunknownagonistDetails
DB11348Calcium PhosphateapprovedunknownagonistDetails
DB13800Calcium levulinateapproved, experimentalunknownagonistDetails
DB14481Calcium phosphate dihydrateapprovedunknownDetails
DB04209Dequaliniumapproved, investigationalunknownantagonistDetails