Biosynthesis of the enediyne antitumor antibiotic C-1027.

Article Details

Citation

Liu W, Christenson SD, Standage S, Shen B

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Science. 2002 Aug 16;297(5584):1170-3.

PubMed ID
12183628 [ View in PubMed
]
Abstract

C-1027 is a potent antitumor agent with a previously undescribed molecular architecture and mode of action. Cloning and characterization of the 85-kilobase C-1027 biosynthesis gene cluster from Streptomyces globisporus revealed (i) an iterative type I polyketide synthase that is distinct from any bacterial polyketide synthases known to date, (ii) a general polyketide pathway for the biosynthesis of both the 9- and 10-membered enediyne antibiotics, and (iii) a convergent biosynthetic strategy for the C-1027 chromophore from four building blocks. Manipulation of genes governing C-1027 biosynthesis allowed us to produce an enediyne compound in a predicted manner.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
MIO-dependent tyrosine 2,3-aminomutaseQ8GMG0Details