1H NMR assignments and secondary structure of human beta 2-microglobulin in solution.
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Okon M, Bray P, Vucelic D
1H NMR assignments and secondary structure of human beta 2-microglobulin in solution.
Biochemistry. 1992 Sep 22;31(37):8906-15.
- PubMed ID
- 1390678 [ View in PubMed]
- Abstract
Sequence-specific resonance assignments of human beta 2-microglobulin (M(r) 12,000) and its secondary structure are determined by 2D NMR techniques. The protein is found to contain two antiparallel beta-sheets each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found. Amide proton-solvent-exchange rate constants and 3JHN alpha coupling constants are evaluated.