Structure of the crystalline complex of deoxycytidylyl-3',5'-guanosine (3',5'-dCpdG) cocrystallized with ribonuclease at 1.9 A resolution.

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Listgarten JN, Maes D, Wyns L, Aguilar CF, Palmer RA

Structure of the crystalline complex of deoxycytidylyl-3',5'-guanosine (3',5'-dCpdG) cocrystallized with ribonuclease at 1.9 A resolution.

Acta Crystallogr D Biol Crystallogr. 1995 Sep 1;51(Pt 5):767-71.

PubMed ID

15299807 [ View in PubMed

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Abstract

The X-ray structure of bovine ribonuclease A cocrystallized with the dinucleotide deoxycytidylyl-3',5'-guanosine has been determined at 1.9 A resolution and refined by restrained least squares to R = 0.218 for 7807 reflections. The structure established that the recently observed retrobound mode of attachment of substrate analogues cytidylyl-2',5'-guanosine and deoxycytidylyl-3',5'-guanosine found in soaked RNase A crystals is also present in the cocrystallized complex. Retrobinding is thus unlikely to be the result of restrictions imposed by the crystalline environment as the ligands soak into the lattice but rather a phenomenon specific to small nucleotides containing guanine.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Deoxycytidylyl-3',5'-guanosine	Ribonuclease pancreatic	Protein	Humans	Unknown	Not Available	Details