Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.
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Offen WA, Zechel DL, Withers SG, Gilbert HJ, Davies GJ
Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.
Chem Commun (Camb). 2009 May 14;(18):2484-6. doi: 10.1039/b902240f. Epub 2009 Apr 6.
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- 19532864 [ View in PubMed]
- Abstract
The Michaelis complex of the beta-mannosidase Man2A shows distortion to a (1)S(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.