Beta-mannosidase
Details
- Name
- Beta-mannosidase
- Synonyms
- Not Available
- Gene Name
- Not Available
- Organism
- Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
- Amino acid sequence
>lcl|BSEQ0022099|Beta-mannosidase MILNLTGKIAPIACGLLCCCSMVYAQGNDTSEVMLLDTGWEFSQSGTEKWMPATVPGTVH QDLISHELLPNPFYGMNEKKIQWVENEDWEYRTSFIVSEEQLNRDGIQLIFEGLDTYADV YLNGSLLLKADNMFVGYTLPVKSVLRKGENHLYIYFHSPIRQTLPQYASNGFNYPADNDH HEKHLSVFSRKAPYSYGWDWGIRMVTSGVWRPVTLRFYDIATISDYYVRQLSLTDENARL SNELIVNQIVPQKIPAEVRVNVSLNGTTVTEVKQQVTLQPGINHITLPAEVTNPVRWMPN GWGTPTLYDFSAQIACGDRIVAEQSHRIGLRTIRVVNEKDKDGESFYFEVNGIPMFAKGA NYIPQDALLPNVTTERYQTLFRDMKEANMNMVRIWGGGTYENNLFYDLADENGILVWQDF MFACTPYPSDPTFLKRVEAEAVYNIRRLRNHASLAMWCGNNEILEALKYWGFEKKFTPEV YQGLMHGYDKLFRELLPSTVKEFDSDRFYVHSSPYLANWGRPESWGTGDSHNWGVWYGKK PFESLDTDLPRFMSEFGFQSFPEMKTIAAFAAPEDYQIESEVMNAHQKSSIGNSLIRTYM ERDYIIPESFEDFVYVGLVLQGQGMRHGLEAHRRNRPYCMGTLYWQLNDSWPVVSWSSID YYGNWKALHYQAKRAFAPVLINPIQQNDSLSVYLISDRLDTMEQMTLEMKVVDFDGKTLG KKIQVHSLEVPANTSKCVYRAKLDGWLTPEDCRRSFLKLILKDKSGHQVAESVHFFRKTK DLQLPPTSVSYQMKQTDGKCELTLFSSMLAKDIFIETPLQGARYSDNFFDLLPGERKKVI ITSPRIKKGEELPVNIKHIRETYK
- Number of residues
- 864
- Molecular Weight
- 99505.545
- Theoretical pI
- 6.25
- GO Classification
- Functionshydrolase activity, hydrolyzing O-glycosyl compoundsProcessescarbohydrate metabolic process
- General Function
- Hydrolase activity, hydrolyzing o-glycosyl compounds
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0022100|Beta-mannosidase ATGATCTTAAATTTGACAGGAAAGATAGCCCCGATAGCATGTGGATTGCTATGTTGCTGT AGTATGGTTTATGCTCAAGGTAATGACACTTCGGAAGTCATGCTACTGGATACCGGTTGG GAATTTTCTCAATCAGGGACTGAAAAGTGGATGCCAGCCACGGTTCCTGGTACGGTTCAT CAGGACCTGATCAGTCATGAATTACTGCCGAATCCTTTTTATGGGATGAATGAAAAGAAA ATTCAATGGGTGGAGAATGAGGACTGGGAATATAGAACCTCCTTTATAGTCTCCGAAGAG CAATTGAATCGTGACGGAATCCAACTTATTTTTGAAGGTCTTGATACCTATGCAGACGTA TATCTCAACGGCTCATTACTGCTGAAGGCTGATAATATGTTTGTGGGTTATACACTTCCT GTAAAATCTGTGTTGCGGAAGGGCGAGAATCACTTATATATTTATTTCCATTCACCTATT CGGCAAACGTTGCCACAATATGCTTCCAATGGCTTCAATTATCCGGCGGATAACGATCAT CACGAGAAACATCTTAGTGTGTTCAGCCGTAAGGCTCCGTATAGTTACGGTTGGGACTGG GGCATCCGAATGGTGACAAGTGGTGTCTGGCGCCCGGTTACTCTTCGTTTTTACGACATA GCTACCATATCCGACTACTATGTCAGACAATTATCGCTGACAGATGAAAACGCTCGTCTG TCTAATGAGCTGATTGTAAACCAGATCGTTCCTCAGAAAATTCCGGCTGAAGTAAGGGTC AATGTATCGTTGAATGGAACTACCGTTACAGAAGTAAAACAGCAGGTGACACTGCAACCC GGGATAAATCATATCACTCTTCCTGCTGAAGTGACGAACCCTGTACGATGGATGCCAAAT GGTTGGGGAACTCCGACTCTGTATGATTTCTCGGCTCAGATAGCTTGTGGAGATCGGATT GTTGCGGAACAATCTCATCGGATTGGTTTACGAACGATTCGTGTGGTAAATGAAAAAGAT AAGGACGGAGAATCTTTTTATTTTGAAGTCAATGGCATACCGATGTTTGCCAAAGGAGCT AATTATATTCCTCAGGATGCACTGCTGCCTAATGTTACTACGGAACGCTATCAGACTTTG TTCCGTGACATGAAGGAGGCCAATATGAATATGGTTCGTATATGGGGTGGTGGGACATAT GAGAATAATCTTTTCTATGACCTTGCCGATGAGAACGGGATACTTGTCTGGCAGGATTTT ATGTTTGCGTGTACCCCTTATCCATCCGATCCTACTTTCCTGAAACGGGTAGAGGCGGAG GCTGTTTACAATATTCGTCGTCTTCGGAATCATGCCTCTTTGGCGATGTGGTGTGGTAAT AATGAAATACTGGAAGCTCTGAAATATTGGGGTTTTGAGAAGAAGTTTACTCCGGAGGTT TATCAAGGATTAATGCATGGTTATGATAAACTGTTCCGTGAGCTGTTGCCTTCAACGGTT AAAGAATTTGATTCGGATCGTTTTTATGTGCACAGTTCGCCTTATCTCGCTAACTGGGGG CGTCCGGAGTCATGGGGGACAGGAGACAGTCATAATTGGGGAGTCTGGTACGGAAAGAAG CCATTTGAGTCTTTAGATACCGATTTGCCGCGTTTTATGAGTGAATTTGGTTTCCAGTCA TTTCCGGAGATGAAAACTATTGCTGCTTTTGCTGCTCCTGAAGATTATCAGATTGAGTCT GAAGTGATGAATGCGCATCAGAAGAGTAGTATTGGTAATTCGTTGATCCGTACTTATATG GAACGTGATTATATCATTCCCGAAAGTTTCGAGGATTTTGTGTATGTCGGATTAGTCTTG CAAGGACAGGGGATGCGGCATGGACTGGAAGCTCACAGACGCAATCGTCCTTATTGTATG GGGACATTGTATTGGCAGTTGAACGACAGTTGGCCGGTAGTATCCTGGTCAAGTATTGAT TATTATGGTAATTGGAAGGCATTACATTATCAGGCAAAGCGTGCTTTTGCACCGGTCTTG ATCAATCCTATACAGCAGAATGACAGTTTGAGTGTCTATCTGATCTCAGACCGGCTTGAT ACAATGGAGCAAATGACATTGGAAATGAAAGTCGTGGATTTTGATGGAAAAACGCTGGGT AAGAAGATACAAGTACATTCGTTGGAAGTTCCGGCAAATACTTCAAAATGTGTTTATCGT GCAAAACTGGATGGCTGGCTGACTCCCGAAGACTGCCGACGTAGCTTCTTGAAATTGATA CTCAAAGATAAATCGGGACATCAGGTGGCTGAGAGCGTCCATTTTTTCAGAAAGACGAAA GATTTGCAACTTCCTCCGACATCAGTATCCTATCAAATGAAGCAGACGGATGGTAAATGT GAATTGACTCTCTTTTCATCAATGTTGGCAAAAGATATTTTTATTGAGACTCCATTGCAA GGAGCCCGTTACAGTGACAACTTCTTTGATCTCTTACCCGGAGAACGTAAGAAAGTAATT ATCACTTCTCCCCGGATAAAGAAGGGAGAAGAATTACCTGTCAATATCAAGCATATTCGA GAAACCTATAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8AAK6 UniProtKB Entry Name Q8AAK6_BACTN GenBank Protein ID 29337303 GenBank Gene ID AE015928 - General References
- Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, Chiang HC, Hooper LV, Gordon JI: A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science. 2003 Mar 28;299(5615):2074-6. [Article]
- Tailford LE, Money VA, Smith NL, Dumon C, Davies GJ, Gilbert HJ: Mannose foraging by Bacteroides thetaiotaomicron: structure and specificity of the beta-mannosidase, BtMan2A. J Biol Chem. 2007 Apr 13;282(15):11291-9. Epub 2007 Feb 7. [Article]
- Tailford LE, Offen WA, Smith NL, Dumon C, Morland C, Gratien J, Heck MP, Stick RV, Bleriot Y, Vasella A, Gilbert HJ, Davies GJ: Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. Nat Chem Biol. 2008 May;4(5):306-12. doi: 10.1038/nchembio.81. [Article]
- Offen WA, Zechel DL, Withers SG, Gilbert HJ, Davies GJ: Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis. Chem Commun (Camb). 2009 May 14;(18):2484-6. doi: 10.1039/b902240f. Epub 2009 Apr 6. [Article]
- Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, Shah N, Wang C, Magrini V, Wilson RK, Cantarel BL, Coutinho PM, Henrissat B, Crock LW, Russell A, Verberkmoes NC, Hettich RL, Gordon JI: Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5859-64. doi: 10.1073/pnas.0901529106. Epub 2009 Mar 24. [Article]