Murine chromosomal location of the mu and kappa opioid receptor genes.

Article Details

Citation

Copy to clipboard

Kozak CA, Filie J, Adamson MC, Chen Y, Yu L

Murine chromosomal location of the mu and kappa opioid receptor genes.

Genomics. 1994 Jun;21(3):659-61.

PubMed ID

7959748 [ View in PubMed

]

Abstract

Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Morphine	Kappa-type opioid receptor	Protein	Humans	Yes	Agonist	Details