von Willebrand factor contaminating porcine factor VIII concentrate (Hyate:C) causes platelet aggregation.

Article Details

Citation

Altieri DC, Capitanio AM, Mannucci PM

von Willebrand factor contaminating porcine factor VIII concentrate (Hyate:C) causes platelet aggregation.

Br J Haematol. 1986 Aug;63(4):703-11.

PubMed ID
2942172 [ View in PubMed
]
Abstract

Severe thrombocytopenia has been reported to occur in some patients treated with a polyelectrolyte-fractionated porcine factor VIII concentrate (Hyate:C) (Kernoff et al, 1984; Gatti & Mannucci, 1984). We report here that Hyate:C induces aggregation of platelet-rich plasma in vitro accompanied by ATP release and thromboxane B2 formation, and is inhibited by EDTA and prostaglandin E1. Hyate:C induced platelet aggregation is affected by monoclonal antibodies anti-glycoprotein Ib or anti-glycoprotein IIb/IIIa and suppressed by polyclonal anti-porcine von Willebrand factor antiserum. We conclude that the aggregating ability of Hyate:C is due to porcine von Willebrand factor present in the concentrate. The occasional thrombocytopenia described after Hyate:C infusions probably results from the interaction between platelets and the porcine von Willebrand factor contaminating the concentrate.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Antihemophilic factor, human recombinantvon Willebrand factorProteinHumans
Yes
Binder
Details
Lonoctocog alfavon Willebrand factorProteinHumans
Yes
Binder
Details
Moroctocog alfavon Willebrand factorProteinHumans
Yes
Binder
Details