[Inhibitors of xanthine oxidoreductase].

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Okamoto K

[Inhibitors of xanthine oxidoreductase].

Nihon Rinsho. 2008 Apr;66(4):748-53.

PubMed ID

18409526 [ View in PubMed

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Abstract

Inhibitors of xanthine oxidoreductase decrease production of uric acid, thus they act as hypouricemic drugs. Allopurinol, a prototypical xanthine oxidoreductase inhibitor, has been widely prescribed for treatment of gout and hyperuricemia. However, severe side effects of allopurinol may occur in patients with renal insufficiency. Recently, novel nonpurine selective inhibitors of xanthine oxidoreductase have been developed as potential alternatives to allopurinol. They have different inhibition mechanisms, utilizing the enzyme structure and the reaction mechanism. Such variation of the inhibition mechanism affects/in vivo/hypouricemic effects of the inhibitors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Allopurinol	Xanthine dehydrogenase/oxidase	Protein	Humans	Yes	Inhibitor	Details