Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.
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Veltel S, Kravchenko A, Ismail S, Wittinghofer A
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.
FEBS Lett. 2008 Jul 23;582(17):2501-7. doi: 10.1016/j.febslet.2008.05.053. Epub 2008 Jun 25.
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- 18588884 [ View in PubMed]
- Abstract
Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.