Genetically engineered poly-gamma-glutamate producer from Bacillus subtilis ISW1214.

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Ashiuchi M, Shimanouchi K, Horiuchi T, Kamei T, Misono H

Genetically engineered poly-gamma-glutamate producer from Bacillus subtilis ISW1214.

Biosci Biotechnol Biochem. 2006 Jul;70(7):1794-7.

PubMed ID
16861819 [ View in PubMed
]
Abstract

The pgsBCA-gene disruptant from Bacillus subtilis ISW1214, i.e., MA41, does not produce poly-gamma-glutamate (PGA). We newly constructed an MA41 recombinant bearing the plasmid-borne PGA synthetic system, in which PGA production was strictly controlled by the use of xylose. Unlike the parent strain, ISW1214, the genetically engineered strain produced abundant PGA in both L-glutamate-rich and D-glutamate-rich media.

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Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Glutamic acidGlutaminase kidney isoform, mitochondrialProteinHumans
Unknown
Not AvailableDetails