Chronic administration of type A monoamine oxidase inhibitors increases duration of thiopentone anaesthesia in the rat.

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Mason ST

Chronic administration of type A monoamine oxidase inhibitors increases duration of thiopentone anaesthesia in the rat.

Physiol Behav. 1985 Aug;35(2):201-3.

PubMed ID

4070383 [ View in PubMed

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Abstract

Daily intraperitoneal administration for fifteen days of the mixed type A and type B monoamine oxidase inhibitors phenelzine, isocarboxazid, iproniazid and tranylcypromine caused a marked increase in the duration of thiopentone anaesthesia ('sleeping time') tested 48 hours after the last drug injection. This effect was not due to accumulation of drug or other carryover since it failed to occur after 5 days of daily administration. Similar prolongation of anaesthesia was seen after 15, but not 5 days of administration of the selective type A monoamine oxidase inhibitors clorgyline and LY 51641 but not with the type B inhibitors pargyline and deprenyl.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Isocarboxazid	Amine oxidase [flavin-containing] B	Protein	Humans	Yes	Inhibitor	Details