Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.
Article Details
- CitationCopy to clipboard
Legler DF, Bruckner M, Uetz-von Allmen E, Krause P
Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.
Int J Biochem Cell Biol. 2010 Feb;42(2):198-201. doi: 10.1016/j.biocel.2009.09.015. Epub 2009 Sep 27.
- PubMed ID
- 19788928 [ View in PubMed]
- Abstract
Prostaglandin E(2) (PGE(2)) is the most abundant eicosanoid and a very potent lipid mediator. PGE(2) is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE(2) acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE(2) is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE(2) synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE(2) receptor antagonism is of great therapeutic interest.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Dinoprostone Prostaglandin E2 receptor EP1 subtype Protein Humans YesAgonistDetails Dinoprostone Prostaglandin E2 receptor EP2 subtype Protein Humans YesAgonistDetails Dinoprostone Prostaglandin E2 receptor EP3 subtype Protein Humans YesAgonistDetails Dinoprostone Prostaglandin E2 receptor EP4 subtype Protein Humans YesAgonistDetails