Doxepin as a blocker of central serotonin receptors.
Article Details
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Maj J, Gancarczyk L, Gorszczyk L, Rawlow A
Doxepin as a blocker of central serotonin receptors.
Pharmakopsychiatr Neuropsychopharmakol. 1977 Dec;10(6):318-24.
- PubMed ID
- 309138 [ View in PubMed]
- Abstract
The antidepressant drug-Doxepin (DX) was examined in order to investigate its central antiserotonin activity. The drug antagonized the behavioral syndrome elecited by L-5-hydroxytryptophan in rats and mice, but did not affect the pinna reflex. In the flexor reflex preparation, DX acted like other sero-tonin receptor blockers: By itself, it had no influence on the flexor reflex but it prevented the potentiation induced by serotonergic agents (fenfluramine, LDS, mescaline). The hyperthermia provoked by serotonergic agent (fenfluramine, LSD)in rabbits was antagonized by DX. DX abolished the syndrome induced by oxotremorine. The results obtained indicate that DX blocks central 5-HT receptors, like the two other antidepressants, mianserin and danitracen.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Doxepin 5-hydroxytryptamine receptor 1A Protein Humans UnknownAntagonistDetails Doxepin 5-hydroxytryptamine receptor 2A Protein Humans UnknownAntagonistDetails Doxepin 5-hydroxytryptamine receptor 2B Protein Humans UnknownAntagonistDetails Doxepin 5-hydroxytryptamine receptor 2C Protein Humans UnknownAntagonistDetails