Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation.

Article Details

Citation

Copy to clipboard

Song Y, Wei EQ, Zhang WP, Zhang L, Liu JR, Chen Z

Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation.

Neuroreport. 2004 Oct 5;15(14):2181-4.

PubMed ID

15371729 [ View in PubMed

]

Abstract

Minocycline protects animals against cerebral ischemia by inhibiting inflammation. To determine whether minocycline protects PC12 cells from in vitro ischemic-like injury and affects pro-inflammatory 5-lipoxygenase activation, the cell viability and 5-lipoxygenase translocation to nuclear membrane were observed after oxygen-glucose deprivation (OGD). We found that OGD reduced cell viability, which was attenuated by minocycline and 5-lipoxygenase inhibitor caffeic acid. 5-Lipoxygenase protein was detected in PC12 cells by immunohistochemical and Western blot analyses. OGD induced 5-lipoxygenase translocation to nuclear membranes, which was abolished by minocycline and caffeic acid. Thus, minocycline can protect PC12 cells from in vitro ischemic-like injury, and this effect may be partly related to the inhibition of 5-lipoxygenase activation.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Minocycline	Arachidonate 5-lipoxygenase	Protein	Humans	Unknown	Inhibitor	Details