Identification and characterization of a prostaglandin transporter.
Article Details
- CitationCopy to clipboard
Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL
Identification and characterization of a prostaglandin transporter.
Science. 1995 May 12;268(5212):866-9.
- PubMed ID
- 7754369 [ View in PubMed]
- Abstract
Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Alprostadil Solute carrier organic anion transporter family member 2A1 Protein Humans UnknownSubstrateDetails Arachidonic Acid Solute carrier organic anion transporter family member 2A1 Protein Humans UnknownSubstrateDetails Dinoprostone Solute carrier organic anion transporter family member 2A1 Protein Humans UnknownSubstrateDetails Furosemide Solute carrier organic anion transporter family member 2A1 Protein Humans UnknownInhibitorDetails Iloprost Solute carrier organic anion transporter family member 2A1 Protein Humans UnknownSubstrateDetails